R
Rory Pritchard
Researcher at University of California, San Diego
Publications - 5
Citations - 120
Rory Pritchard is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Nociception & Neurotransmitter. The author has an hindex of 3, co-authored 5 publications receiving 82 citations.
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Journal ArticleDOI
Increased miR-132-3p expression is associated with chronic neuropathic pain.
TL;DR: Results indicate a pro-nociceptive effect of miR-132-3p in chronic neuropathic pain in patients with peripheral neuropathies and in an animal model of neuropathy pain.
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Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.
Gustaf Wigerblad,J.R. Huie,Hong Zhen Yin,Mathias Leinders,Rory Pritchard,Fred J. Koehrn,Wen Hua Xiao,Gary J. Bennett,Richard L. Huganir,Adam R. Ferguson,John H. Weiss,Camilla I. Svensson,Linda S. Sorkin +12 more
TL;DR: Data suggest that peripheral inflammation induces a PI3K and PKA dependent TNFR1 activated pathway that culminates with trafficking of calcium permeable AMPAr into synapses of nociceptive dorsal horn projection neurons.
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Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation
TL;DR: The data indicate that pain and clinical inflammation are pharmacologically separable and may help to explain clinical conditions in which inflammation naturally wanes or goes into remission, but pain continues unabated.
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Photoperiod-induced neurotransmitter plasticity declines with aging: An epigenetic regulation?
TL;DR: Reciprocal histone acetylation in TH+ and SST+ neurons indicates the importance of studying epigenetic regulation at the circuit level for identified cell phenotypes and may be useful for developing approaches for noninvasive treatment of disorders characterized by neurotransmitter dysfunction.
Posted ContentDOI
Photoperiod-induced neurotransmitter plasticity declines with aging: an epigenetic regulation?
TL;DR: It is shown that age-dependent reduction in neurotransmitter plasticity is robust at 1 and at 3 months but reduced in TH+ neurons at 12 months and completely abolished in both TH+ and SST+ neurons by 18 months, which indicates the importance of studying epigenetic regulation at the circuit level for identified cell phenotypes.