Showing papers by "Rosa M. Claramunt published in 1986"
TL;DR: The structure of indazolinone and some of its derivatives was obtained by the combined use of crystallography, 13C CP/MAS, and 15N n.m. as mentioned in this paper.
Abstract: The structure of indazolinone and some of its derivatives was obtained by the combined use of crystallography, 13C CP/MAS, and 15N n.m.r. It was concluded that indazolinone exists as such in the solid state but only as a minor tautomer (15%) in DMSO solution, where the 3-hydroxyindazole tautomer predominates (85%). The result of bromination of indazolinone is reported. Two acylhydrazines, as open analogues of indazolinone, were studied as model compounds.
19 citations
TL;DR: In this paper, the crystal structures of 1-(1-adamantyl)-3,5-dimethyl pyrazole 1 and 1-(3,4,5)-trimethylpyrazole 2 were studied by X-ray analysis.
11 citations
TL;DR: A number of mesoionic derivatives of the 1,2,4-triazolo ring system have been prepared from 4-amino-1 -methyl -3,5-bis(methylthio)-1, 2,4,triazolium cation and aryl isothiocyanates as discussed by the authors.
9 citations
TL;DR: The results suggest that 4-nitropyrazoles, as well as 4,4'-dinitro-1, 1'-methylene-dipyrazole, should be investigated further as alternatives to, or even substitutes for, the currently used nitroimidazoles.
Abstract: The mutagenicity of pyrazole and seven pyrazole derivatives (4-nitropyrazole, 4-bromopyrazole, 1-methyl-4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 1-methyl-4-bromopyrazole, 4,4'-dinitro-1, 1'-methylene-dipyrazole and 4,4'-dibromo-1,1'-methylene-dipyrazole) has been investigated with the L-arabinose forward mutation assay of Salmonella typhimurium. Two nitroimidazoles (1-methyl-5-nitroimidazole and metronidazole) were included as reference drugs. The mutagenicity of each chemical was determined by both preincubation and liquid tests, in the presence or absence of S9 microsomal fraction. The mutagenic responses was expressed as the absolute number of L-arabinose resistant mutants growing in selective plates, supplemented with traces of D-glucose. Strain BA13 with a wild-type lipopolysaccharide barrier was used as a comparison to the deep rough derivative BA9. No mutagenic effect was detected with pyrazole and two of its derivatives, 1-methyl-4-bromopyrazole and 4,4'-dibromo-1,1'-methylene-dipyrazole. The other five pyrazole derivatives were mutagenic to different degrees, although their mutagenic potencies were always considerably lower than those of the two nitroimidazoles. The results suggest that 4-nitropyrazoles, as well as 4,4'-dinitro-1, 1'-methylene-dipyrazoles, should be investigated further as alternatives to, or even substitutes for, the currently used nitroimidazoles.
8 citations