R
Rosanna Upstill-Goddard
Researcher at University of Glasgow
Publications - 19
Citations - 1103
Rosanna Upstill-Goddard is an academic researcher from University of Glasgow. The author has contributed to research in topics: Pancreatic cancer & Promoter. The author has an hindex of 10, co-authored 17 publications receiving 810 citations. Previous affiliations of Rosanna Upstill-Goddard include Southampton General Hospital & University of Southampton.
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Journal ArticleDOI
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
Colin W. Steele,Saadia A. Karim,Joshua D.G. Leach,Peter Bailey,Rosanna Upstill-Goddard,Loveena Rishi,Mona Foth,Sheila Bryson,Karen McDaid,Zena Wilson,Catherine Anne Eberlein,Juliana Candido,Mairi Clarke,Colin Nixon,John T. Connelly,Nigel B. Jamieson,C. Ross Carter,Frances R. Balkwill,David K. Chang,T.R. Jeffry Evans,Douglas Strathdee,Andrew V. Biankin,Robert J. B. Nibbs,Simon T. Barry,Owen J. Sansom,Jennifer P. Morton +25 more
TL;DR: It is shown that CXCR2 signaling in the myeloid compartment can promote pancreatic tumorigenesis and is required for pancreatic cancer metastasis, making it an excellent therapeutic target.
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Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes
Katja Christodoulou,A E Wiskin,Jane Gibson,William J. Tapper,Claire Willis,Nadeem A. Afzal,Rosanna Upstill-Goddard,John W. Holloway,Michael A. Simpson,R Mark Beattie,Andrew Collins,Sarah Ennis +11 more
TL;DR: All non-synonymous, truncating and frameshift mutations across all known IBD genes were identified and a unique profile of rare and potentially damaging variants was evident for each patient with this complex disease.
Journal ArticleDOI
Machine learning approaches for the discovery of gene–gene interactions in disease data
TL;DR: Recent and current approaches focusing on applications to real data, particularly in the context of genome-wide association studies and looking ahead to the further challenges posed by next generation sequencing data are reviewed.
Journal ArticleDOI
Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma.
Nathiya Muthalagu,Tiziana Monteverde,Ximena L. Raffo-Iraolagoitia,Robert Wiesheu,Declan Whyte,Ann Hedley,Sarah Laing,Björn Kruspig,Rosanna Upstill-Goddard,Robin M. Shaw,Sarah Neidler,Curtis J. Rink,Saadia A. Karim,Katarina Gyuraszova,Colin Nixon,William C. Clark,Andrew V. Biankin,Leo M. Carlin,Seth B. Coffelt,Owen J. Sansom,Jennifer P. Morton,Daniel J. Murphy +21 more
TL;DR: It is shown that this level of MYC alone suffices to drive pancreatic neuroendocrine tumours, and to accelerate progression of KRAS-initiated precursor lesions to metastatic pancreatic ductal adenocarcinoma.
Journal ArticleDOI
Defining the molecular pathology of pancreatic body and tail adenocarcinoma
Stephan Dreyer,Nigel B. Jamieson,Nigel B. Jamieson,Rosanna Upstill-Goddard,Peter Bailey,Colin J. McKay,Colin J. McKay,Andrew V. Biankin,Andrew V. Biankin,David K. Chang,David K. Chang +10 more
TL;DR: The aim was to investigate the molecular differences between PDAC of the head and those of the body and tail of the pancreas.