M
Mairi Clarke
Researcher at University of Glasgow
Publications - 29
Citations - 2279
Mairi Clarke is an academic researcher from University of Glasgow. The author has contributed to research in topics: Ubiquitin & Carcinogenesis. The author has an hindex of 14, co-authored 26 publications receiving 1804 citations. Previous affiliations of Mairi Clarke include European Bioinformatics Institute.
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Journal ArticleDOI
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
Colin W. Steele,Saadia A. Karim,Joshua D.G. Leach,Peter Bailey,Rosanna Upstill-Goddard,Loveena Rishi,Mona Foth,Sheila Bryson,Karen McDaid,Zena Wilson,Catherine Anne Eberlein,Juliana Candido,Mairi Clarke,Colin Nixon,John T. Connelly,Nigel B. Jamieson,C. Ross Carter,Frances R. Balkwill,David K. Chang,T.R. Jeffry Evans,Douglas Strathdee,Andrew V. Biankin,Robert J. B. Nibbs,Simon T. Barry,Owen J. Sansom,Jennifer P. Morton +25 more
TL;DR: It is shown that CXCR2 signaling in the myeloid compartment can promote pancreatic tumorigenesis and is required for pancreatic cancer metastasis, making it an excellent therapeutic target.
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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Thomas Jamieson,Mairi Clarke,Colin W. Steele,Michael S. Samuel,Jens Neumann,Andreas Jung,David J. Huels,Michael F. Olson,Sudipto Das,Robert J. B. Nibbs,Owen J. Sansom +10 more
TL;DR: CXCR2 is a potent protumorigenic chemokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during tumor-inducing and tumor-driven inflammation and may have therapeutic and prophylactic potential in the treatment of cancer.
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GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system
TL;DR: Recombinant GRASP55 and antibodies to the protein block the stacking of Golgi cisternae, which is similar to the observations made for GRasP65.
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The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis.
TL;DR: Data show that endogenous Rab6‐KIFL functions in cell division during cleavage furrow formation and cytokinesis, in addition to its previously described role in membrane traffic.
Journal ArticleDOI
Structure and assembly of the Ebola virus nucleocapsid.
William Wan,Larissa Kolesnikova,Mairi Clarke,Alexander Koehler,Takeshi Noda,Takeshi Noda,Stephan Becker,John A. G. Briggs +7 more
TL;DR: Cryo-electron tomography and subtomogram averaging reveal the identity and arrangement of the nucleocapsid components, and suggest that the formation of an extended α-helix from the disordered carboxy-terminal region of nucleoprotein-core links nucleop protein oligomerization, nucleocapid condensation, RNA encapsidation, and accessory protein recruitment.