R
Rose P. Webster
Researcher at University of Cincinnati
Publications - 14
Citations - 652
Rose P. Webster is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Preeclampsia & Peroxynitrite. The author has an hindex of 11, co-authored 14 publications receiving 599 citations. Previous affiliations of Rose P. Webster include University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Vascular biology of preeclampsia
Leslie Myatt,Rose P. Webster +1 more
TL;DR: The vascular stress test of pregnancy identifies women with a previously unrecognized at risk vascular system and promotes the development of preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria and edema that resolves on delivery of the placenta.
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Protein Nitration in Placenta – Functional Significance
TL;DR: The targets and extent of nitration of enzymes, receptors, transporters and structural proteins may markedly influence placental cellular function in both physiologic and pathologic settings.
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Glucocorticoids Induce Cytosolic Phospholipase A2 and Prostaglandin H Synthase Type 2 but Not Microsomal Prostaglandin E Synthase (PGES) and Cytosolic PGES Expression in Cultured Primary Human Amnion Cells
TL;DR: Amnion fibroblasts express a higher level of PGHS-2 mRNA and produced more PGE(2) per cell than amnion epithelial cells at term of human pregnancy.
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Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia
TL;DR: Investigation of nitrotyrosine immunostaining in placental villous vascular endothelium, surrounding vascular smooth muscle and villous stroma from pre-eclamptic or diabetic pregnancies and catalytic activity of p38 MAPK found to be reduced found increased nitration of phospho-p38 mitogen-activated protein kinase (MAPK) in the pre- eClamptic placenta.
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Post-Translational Modifications of the P2X4 Purinergic Receptor Subtype in the Human Placenta are Altered in Preeclampsia
TL;DR: It is proposed that P2X(4) acts within the syncytiotrophoblast to alter intracellular calcium and subsequent signalling pathways thereby restoring placental cell homeostasis following ATP-induced changes during pathophysiological conditions such as preeclampsia.