Journal ArticleDOI
Post-Translational Modifications of the P2X4 Purinergic Receptor Subtype in the Human Placenta are Altered in Preeclampsia
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TLDR
It is proposed that P2X(4) acts within the syncytiotrophoblast to alter intracellular calcium and subsequent signalling pathways thereby restoring placental cell homeostasis following ATP-induced changes during pathophysiological conditions such as preeclampsia.About:
This article is published in Placenta.The article was published on 2007-04-01. It has received 31 citations till now. The article focuses on the topics: Placenta & Syncytiotrophoblast.read more
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Journal ArticleDOI
P2 receptors in cardiovascular regulation and disease
David Erlinge,Geoffrey Burnstock +1 more
TL;DR: The dual role of ATP in regulation of vascular tone, released as a cotransmitter from sympathetic nerves or released in the vascular lumen in response to changes in blood flow and hypoxia is considered.
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Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta
TL;DR: It is hypothesized that nitration of proteins in the placenta including receptors, transporters, enzymes and structural proteins can alter protein and placental function and this influences fetal growth and development.
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Purinergic Signalling: Therapeutic Developments.
TL;DR: Investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer.
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Vascular biology of preeclampsia
Leslie Myatt,Rose P. Webster +1 more
TL;DR: The vascular stress test of pregnancy identifies women with a previously unrecognized at risk vascular system and promotes the development of preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria and edema that resolves on delivery of the placenta.
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Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta.
Victoria H. J. Roberts,Jessica Smith,Stacey A. McLea,Angela B. Heizer,Jade L. Richardson,Leslie Myatt +5 more
TL;DR: It is demonstrated that with increasing maternal body mass index there is an increase in placental nitrative stress, but there does not appear to be a corresponding increase in oxidative stress and indeed there is some evidence of a decrease in oxidative effects in these placenta samples.
References
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Journal ArticleDOI
Molecular Physiology of P2X Receptors
TL;DR: P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP and are involved in the initiation of afferent signals in several viscera and play a key role in sensing tissue-damaging and inflammatory stimuli.
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Extracellular ATP: effects, sources and fate.
TL;DR: The main purpose of this Review is to summarize current knowledge of these topics and to indulge in some modest speculation about the role of extracellular ATP in biology and pathology.
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Oxidative stress in the placenta
Leslie Myatt,Xiaolan Cui +1 more
TL;DR: In late gestation increased oxidative stress is seen in pregnancies complicated by diabetes, IUGR, and preeclampsia in association with increased trophoblast apoptosis and deportation and altered placental vascular reactivity.
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Protein Nitration in Cardiovascular Diseases
Illarion V. Turko,Ferid Murad +1 more
TL;DR: The goal of this review is to attract more attention to identification of specific proteins, which undergo tyrosine nitration and to study a correlation between their altered function and pathology.
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Biological significance of nitric oxide-mediated protein modifications.
TL;DR: Two particular modifications of NO have recently received much attention, nitrosylation of thiols to produce S-nitrosothiol and nitration of tyrosine residues to produce nitrotyrosine, and the possibility that these modifications may play a role in NO-mediated signaling is examined.