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Roseann Petersen
Researcher at Pfizer
Publications - 4
Citations - 1147
Roseann Petersen is an academic researcher from Pfizer. The author has contributed to research in topics: Hsp90 & Protein kinase B. The author has an hindex of 4, co-authored 4 publications receiving 1128 citations.
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Journal ArticleDOI
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
Mehran S. Neshat,Ingo K. Mellinghoff,Chris Tran,Bangyan L. Stiles,George Thomas,Roseann Petersen,Philip Frost,James Joseph Gibbons,Hong Wu,Charles L. Sawyers +9 more
TL;DR: In vitro and in vivo studies of isogenic PTEN+/+ and PTEN−/− mouse cells as well as human cancer cells with defined PTEN status showed that the growth of PTEN null cells was blocked preferentially by pharmacologic FRAP/mTOR inhibition, indicating that FRAP-mTOR functions downstream of Akt in tumorigenesis.
Journal ArticleDOI
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Ariamala Gopalsamy,Mengxiao Shi,Jennifer M. Golas,Erik Vogan,Jaison Jacob,Mark S. Johnson,Frederick Lee,Ramaswamy Nilakantan,Roseann Petersen,Kristin Svenson,Rajiv Chopra,May S. Tam,Yingxia Wen,John W. Ellingboe,Kim Arndt,Frank Boschelli +15 more
TL;DR: Small-molecule benzisoxazole derivatives as Hsp90 inhibitors are identified and structure based optimization led to the identification of potent analogues, such as 13, with good biochemical profiles.
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PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Ker Yu,Judy Lucas,Tianmin Zhu,Arie Zask,Christine Gaydos,Lourdes Toral-Barza,Jianxin Gu,Fangbiao Li,Inder Chaudhary,Ping Cai,Jason Arnold Lotvin,Roseann Petersen,Mark Edward Ruppen,Mahdi Fawzi,Semiramis Ayral-Kaloustian,Jerauld S. Skotnicki,Tarek S. Mansour,Philip Frost,James Joseph Gibbons +18 more
TL;DR: PWT-458 is identified as an effective anticancer agent and strong proof-of-principle for targeting the PI3K pathway as novel anticancer therapy is provided.
Journal ArticleDOI
A cell-based screen for inhibitors of protein folding and degradation.
Frank Boschelli,Jennifer M. Golas,Roseann Petersen,Vincent Lau,Lei Chen,Diane Tkach,Qiang Zhao,Dave S. Fruhling,Hao Liu,Chaneun Nam,Kim Arndt +10 more
TL;DR: A simple screen for inhibitors of protein synthesis, folding, and proteasomal degradation pathways is described, and the largest group of compounds identified in the screen increased luciferase activity, and some of these increase v-Src levels and activity.