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Bangyan L. Stiles
Researcher at University of Southern California
Publications - 68
Citations - 5212
Bangyan L. Stiles is an academic researcher from University of Southern California. The author has contributed to research in topics: PTEN & Protein kinase B. The author has an hindex of 32, co-authored 60 publications receiving 4538 citations. Previous affiliations of Bangyan L. Stiles include University of California, Los Angeles & Howard Hughes Medical Institute.
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Journal ArticleDOI
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
Mehran S. Neshat,Ingo K. Mellinghoff,Chris Tran,Bangyan L. Stiles,George Thomas,Roseann Petersen,Philip Frost,James Joseph Gibbons,Hong Wu,Charles L. Sawyers +9 more
TL;DR: In vitro and in vivo studies of isogenic PTEN+/+ and PTEN−/− mouse cells as well as human cancer cells with defined PTEN status showed that the growth of PTEN null cells was blocked preferentially by pharmacologic FRAP/mTOR inhibition, indicating that FRAP-mTOR functions downstream of Akt in tumorigenesis.
Journal ArticleDOI
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
Bangyan L. Stiles,Ying Wang,Andreas Stahl,Sara Bassilian,W. Paul Lee,Yoon-Jung Kim,Robert S. Sherwin,Sherin U. Devaskar,Ralf Lesche,Mark A. Magnuson,Hong Wu +10 more
TL;DR: Deletion of Pten in the liver resulted in increased fatty acid synthesis, accompanied by hepatomegaly and fatty liver phenotype, and PTEN may be a promising target for therapeutic intervention for type 2 diabetes.
Journal ArticleDOI
PTEN: Tumor Suppressor and Metabolic Regulator.
TL;DR: The role of PTEN in glycolysis, gluconeogenesis, glycogen synthesis, lipid metabolism as well as mitochondrial metabolism, and the PTEN-regulated signals in metabolic regulation were focused on.
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Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
Ben Z. Stanger,Bangyan L. Stiles,Gregory Y. Lauwers,Nabeel Bardeesy,Michael Mendoza,Ying Wang,Amy Greenwood,Kuang Hung Cheng,Margaret McLaughlin,Dennis Brown,Ronald A. DePinho,Hong Wu,Douglas A. Melton,Yuval Dor,Yuval Dor +14 more
TL;DR: Results indicate that Pten actively maintains the balance between different cell types in the adult pancreas and that misregulation of the PI3-K pathway in centroacinar cells may contribute to the initiation of pancreatic carcinoma in vivo.
Journal ArticleDOI
PTENless means more.
TL;DR: The function of PTEN in murine development and its role in regulating stem cell self-renewal and proliferation are focused on and the organomegaly phenotypes associated with Pten tissue-specific deletion are summarized.