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Rosemary Clark
Researcher at Menzies Research Institute
Publications - 16
Citations - 223
Rosemary Clark is an academic researcher from Menzies Research Institute. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor cortex. The author has an hindex of 7, co-authored 16 publications receiving 174 citations. Previous affiliations of Rosemary Clark include United States Geological Survey.
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Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies
Emily E Handley,Kimberley A Pitman,Edgar Dawkins,Kaylene M. Young,Rosemary Clark,Tongcui C Jiang,Bradley J. Turner,Tracey C. Dickson,Catherine A. Blizzard +8 more
TL;DR: It is concluded that mutated TDP-43 has a significant pathological effect at the dendritic spine that is associated with attenuated neural transmission and reduced efficacy of synaptic transmission as determined by electrophysiology at P60.
Journal ArticleDOI
Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1 G93A mouse model of ALS
TL;DR: It is concluded that a differential capacity for interneurons exists in the ALS motor cortex, which may not be a static phenomenon, but involves early dynamic changes throughout disease, implicating specific inhibitory circuitry.
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Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function.
Tongcui Jiang,Emily E Handley,Mariana Brizuela,Edgar Dawkins,Katherine E. A. Lewis,Rosemary Clark,Tracey C. Dickson,Catherine A. Blizzard +7 more
TL;DR: This work reveals a crucial effect of the over-expression mutation TDP-43A315T on the formation of synaptic structures and the recruitment of GluR1 to the synaptic membrane and implicates hypoexcitability and attenuated synaptic function in the pathogenic decline of neuronal function in T DP-43-associated ALS.
Journal ArticleDOI
Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain.
Shiwei Wang,Marta Bolós,Rosemary Clark,Carlie L. Cullen,Katherine A. Southam,Lisa Foa,Tracey C. Dickson,Kaylene M. Young +7 more
TL;DR: It is concluded that APP reduces the survival of newborn neurons in the olfactory bulb and hippocampus, but that it does not influence all neuronal subtypes equally.
Identification of a New Spinel-Rich Lunar Rock Type by the Moon Mineralogy Mapper (M (sup 3))
C. M. Pieters,Joseph W. Boardman,B. J. Buratti,Rosemary Clark,J. P. Combe,Robert O. Green,J. N. Goswami,J. W. Head,Michael D. Hicks,Peter J. Isaacson,Rachel L. Klima,Georgiana Y. Kramer,K. Kumar,S. Lundeen,Erick Malaret,T. B. McCord,J. M. Mustard,J. Nettles,Noah E. Petro,C. Runyon,M. Staid,J. M. Sunshine,Lawrence A. Taylor,K. G. Thaisen,Stefanie Tompkins +24 more
TL;DR: A new rock type was detected on the farside of the Moon by the Moon Mineralogy Mapper (M3) on Chandrayaan-1 that does not easily fit with current crustal evolution models.