R
Rosemary Pike
Researcher at Randall Division of Cell and Molecular Biophysics
Publications - 3
Citations - 60
Rosemary Pike is an academic researcher from Randall Division of Cell and Molecular Biophysics. The author has contributed to research in topics: Ligand (biochemistry) & Cell signaling. The author has an hindex of 3, co-authored 3 publications receiving 36 citations. Previous affiliations of Rosemary Pike include King's College London.
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Journal ArticleDOI
KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
Rosemary Pike,Elena Ortiz-Zapater,Elena Ortiz-Zapater,Brooke Lumicisi,George Santis,Maddy Parsons +5 more
TL;DR: Depletion of CAR in human lung cancer cells reduced anchorage-independent growth, epidermal growth factor (EGF)–dependent proliferation, and tumor growth in vivo and suggest a role for KIF22 in the coordination of membrane receptors and provide potential new therapeutic strategies to combat lung tumor growth.
Journal ArticleDOI
TNFR1 membrane reorganization promotes distinct modes of TNFα signaling
Penny E. Morton,Camille Perrin,James A. Levitt,Daniel R. Matthews,Richard J. Marsh,Rosemary Pike,David McMillan,Alison Maloney,Simon P. Poland,Simon Ameer-Beg,Maddy Parsons +10 more
TL;DR: It is confirmed that TNFR1 forms preassembled clusters at the plasma membrane of adherent cells in the absence of ligand, and data suggest that distinct modes of TNfr1 signaling depend on nanoscale changes in receptor organization.
Journal ArticleDOI
TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.
Penny E. Morton,Alexander Hicks,Elena Ortiz-Zapater,Swetavalli Raghavan,Rosemary Pike,Alistair Noble,Abigail Woodfin,Gisli Jenkins,Emma Rayner,George Santis,Maddy Parsons +10 more
TL;DR: It is shown that TNFα acts in a paracrine manner on epithelial cells via a TNFR1-PI3K-PKCδ pathway leading to CAR phosphorylation and subsequent transmigration across cell junctions, and that CAR is hyper-phosphorylated in vivo in acute and chronic lung inflammation models and this response is required to facilitate immune cell recruitment.