R
Rossella Baldan
Researcher at University of East Anglia
Publications - 5
Citations - 420
Rossella Baldan is an academic researcher from University of East Anglia. The author has contributed to research in topics: Nanopore sequencing & Metagenomics. The author has an hindex of 3, co-authored 5 publications receiving 200 citations. Previous affiliations of Rossella Baldan include Guy's and St Thomas' NHS Foundation Trust & St Thomas' Hospital.
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Journal ArticleDOI
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.
Themoula Charalampous,Gemma L. Kay,Gemma L. Kay,Hollian Richardson,Alp Aydin,Rossella Baldan,Rossella Baldan,Christopher Jeanes,Duncan Rae,Sara Grundy,Daniel J. Turner,John Wain,John Wain,Richard M. Leggett,David M. Livermore,David M. Livermore,Justin O'Grady,Justin O'Grady +17 more
TL;DR: Nanopore sequencing coupled with a metagenomics framework that effectively removes human DNA from samples enables rapid bacterial LRI diagnosis and might contribute to a reduction in broad-spectrum antibiotic use.
Posted ContentDOI
Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical Metagenomics
Themoula Charalampous,Hollian Richardson,Gemma L. Kay,Rossella Baldan,Rossella Baldan,Christopher Jeanes,Duncan Rae,Sara Grundy,Daniel J. Turner,John Wain,John Wain,Richard M. Leggett,David M. Livermore,David M. Livermore,Justin O'Grady,Justin O'Grady +15 more
TL;DR: It is demonstrated that nanopore metagenomics can rapidly and accurately characterise bacterial LRIs when combined with efficient human DNA depletion.
Posted ContentDOI
Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study
Virve I. Enne,Alp Aydin,Rossella Baldan,Rossella Baldan,Dewi R Owen,Hollian Richardson,Federico Ricciardi,Charlotte Russell,Brenda O. Nomamiukor-Ikeji,Ann Marie Swart,Juliet High,Antony Colles,Julie Barber,Vanya Gant,David M. Livermore,Justin O'Grady,Justin O'Grady +16 more
TL;DR: Two PCR platforms for HAP/VAP diagnosis against routine microbiology (RM) are compared, identifying one to progress into a Randomised Controlled Trial (RCT) and the increased sensitivity of detection realised by PCR offers potential for improved antimicrobial prescribing.
Journal ArticleDOI
Development and evaluation of a nanopore 16S rRNA gene sequencing service for same day targeted treatment of bacterial respiratory infection in the intensive care unit.
Rossella Baldan,Rossella Baldan,Penelope R. Cliff,Sarah Burns,Sarah Burns,Adela Medina,Graeme C. Smith,Rahul Batra,Rahul Batra,Alberto Cerda,Rebekah Wilson,Tammy Merrill,Shona J. Lewis,Amita Patel,Amita Patel,Dakshika Jeyaratnam,Duncan Wyncoll,Nicholas A Barrett,Meera Chand,Jonathan D. Edgeworth,Jonathan D. Edgeworth,Jonathan D. Edgeworth +21 more
TL;DR: In this article, the feasibility and impact of nanopore-based 16S rRNA gene sequencing (Np16S) service on antibiotic treatment for acute severe pneumonia on the intensive care unit (ICU).
Proceedings ArticleDOI
Diagnosis of Lower Respiratory Tract Infections using nanopore sequencing
Themoula Charalampous,Hollian Richardson,Gemma L. Kay,Rossella Baldan,Christopher Jeanes,Daniel J. Turner,John Wain,David M. Livermore,Richard M. Leggett,Justin O'Grady +9 more
TL;DR: LRTI pathogens and antibiotic resistance genes were identified within 6hrs with the developed metagenomics sequencing pipeline, demonstrating that metagenomic sequencing has the potential to replace culture.