R
Roswitha Löwer
Researcher at Paul Ehrlich Institute
Publications - 37
Citations - 3387
Roswitha Löwer is an academic researcher from Paul Ehrlich Institute. The author has contributed to research in topics: Endogenous retrovirus & Retrovirus. The author has an hindex of 27, co-authored 37 publications receiving 3211 citations.
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Journal ArticleDOI
The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences
TL;DR: The demonstrable and potential roles of HTDV/HERV-K as well as of other human elements in disease and in maintaining genome plasticity are illustrated.
Journal ArticleDOI
Identification of human endogenous retroviruses with complex mRNA expression and particle formation.
Roswitha Löwer,Klaus Boller,Brigitte Hasenmaier,Christine Korbmacher,Nikolaus Muller-Lantzsch,Johannes Löwer,Reinhard Kurth +6 more
TL;DR: In this article, the expression pattern of a family of human endogenous retrovirus sequences (HERV-K) in GH cells, a teratocarcinoma cell line producing the human TERATOCCARINoma-derived retrovirirus (HTDV) particles previously described by us, was described.
Journal ArticleDOI
Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.
TL;DR: The human endogenous retrovirus family HTDV/HERV-K codes for the viral particles observed in teratocarcinoma cell lines, and secondary structure analysis reveals similarities to basic helix-loop-helix proteins.
Journal ArticleDOI
Evidence That HERV-K Is the Endogenous Retrovirus Sequence That Codes for the Human Teratocarcinoma-Derived Retrovirus HTDV
Klaus Boller,Herbert König,Marlies Sauter,Nikolaus Mueller-Lantzsch,Roswitha Löwer,Johannes Löwer,Reinhard Kurth +6 more
TL;DR: Results provide evidence that HERV-K codes for HTDV, an expressed human endogenous retrovirus sequence that is regularly observed by electron microscopy at low frequency in cell lines established from human teratocarcinomas.
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The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery
Julija Raiz,Annette Damert,Sergiu Chira,Ulrike Held,Sabine Klawitter,Matthias Hamdorf,Johannes Löwer,Wolf H. Strätling,Roswitha Löwer,Gerald G. Schumann +9 more
TL;DR: It is demonstrated that SVA elements are mobilized in HeLa cells only in the presence of both L1-encoded proteins, ORF1p and ORF2p, and SVA trans-mobilization rates exceeded pseudogene formation frequencies by 12- to 300-fold in He La-HA cells, indicating that S VA elements represent a preferred substrate for L1 proteins.