So far in this course we have dealt entirely with the evolution of characters that are controlled by simple Mendelian inheritance at a single locus. There are notes on the course website about gametic disequilibrium and how allele frequencies change at two loci simultaneously, but we didn’t discuss them. In every example we’ve considered we’ve imagined that we could understand something about evolution by examining the evolution of a single gene. That’s the domain of classical population genetics. For the next few weeks we’re going to be exploring a field that’s actually older than classical population genetics, although the approach we’ll be taking to it involves the use of population genetic machinery. If you know a little about the history of evolutionary biology, you may know that after the rediscovery of Mendel’s work in 1900 there was a heated debate between the “biometricians” (e.g., Galton and Pearson) and the “Mendelians” (e.g., de Vries, Correns, Bateson, and Morgan). Biometricians asserted that the really important variation in evolution didn’t follow Mendelian rules. Height, weight, skin color, and similar traits seemed to

Human biochemical genetics

世界経済・社会統計 = World development indicators

计量经济分析 = Econometric analysis

How has Japan become a major economic power, a world leader in the automotive and electronics industries? What is the secret of their success? The consensus has been that, though the Japanese are not particularly innovative, they are exceptionally skilful at imitation, at improving products that already exist. But now two leading Japanese business experts, Ikujiro Nonaka and Hiro Takeuchi, turn this conventional wisdom on its head: Japanese firms are successful, they contend, precisely because they are innovative, because they create new knowledge and use it to produce successful products and technologies. Examining case studies drawn from such firms as Honda, Canon, Matsushita, NEC, 3M, GE, and the U.S. Marines, this book reveals how Japanese companies translate tacit to explicit knowledge and use it to produce new processes, products, and services.

The knowledge-creating company : how Japanese companies create the dynamics of innovation

The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

Integrative analysis of 111 reference human epigenomes

Technostress is an important by-product of information and communication technologies (ICT). The technostress literature suggests focusing on specific dimensions of technostress, such as techno-overload, which describes when ICT usage demands to work faster and longer. However, only a few studies have dealt with the technostress of small business owners, let alone techno-overload. This is surprising since work overload in general has been identified as an important dimension of job stress for small business owners, and technostress has been identified as an important impediment for workers in general. The aim of the current study is to investigate the effect of techno-overload on well-being outcomes (as a composite measure consisting of physical well-being, mental well-being, sleep quality, burnout, and loneliness) using three data sets of French small business owners. Our results indicate a strong negative correlation between techno-overload and our composite measure of well-being for all three data sets. We interpret our findings for several different disciplines: information systems, small business owners and entrepreneurship, health and well-being, psychology and organization studies. Our data also allow for the identification of contextual effects – the COVID-19 pandemic – since one survey was conducted before, one at the start of, and one during the pandemic. 

Techno-overload and well-being of French small business owners: identifying the flipside of digital technologies

textOverconfidence has been proposed as an explanation for excess market entry by entrepreneurs and low returns in entrepreneurial activities. However, establishing that entrepreneurs are more overconfident than non-entrepreneurs requires the use of representative population samples; in addition, econometric endogeneity issues in survey data must be addressed. To overcome these methodological challenges, we use a measure of overconfidence that employs self-reports of life expectancy. These self-reports are compared to actual life spans in a large sample of the US population. We show that entrepreneurs are indeed more overconfident than non-entrepreneurs. By using fixed-effects panel regression—and thus by exploiting the longitudinal nature of our data—we provide evidence that changes in entrepreneurial status are not associated with changes in subjective life expectancy. These two findings in combination offer evidence that overconfident individuals self- select into entrepreneurship.

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Living Forever: Entrepreneurial Overconfidence at Older Ages

/pdf/business-ownership-and-economic-grow-t-h-an-empirical-inve-s-50ibsa4jyb.pdf

Business Ownership and Economic Grow t h : An Empirical Inve s t i g a t i o n

https://www.erudit.org/en/journals/mi/2019-v23-n5-mi05077/1066706ar.pdf

Mot des rédacteurs invités : entre logiques individuelles et collectives, aux fondements de la société entrepreneuriale / Word from the Guest Editors: Between Individual and Collective Logics, Toward the Foundations of the Entrepreneurial Society / Palabras de redactores editores invitados: Entre las lógicas individuales y colectivas, hacia los fundamentos de la sociedad emprendedora

Roy Thurik

Papers

Techno-overload and well-being of French small business owners: identifying the flipside of digital technologies

Living Forever: Entrepreneurial Overconfidence at Older Ages

Business Ownership and Economic Grow t h : An Empirical Inve s t i g a t i o n

Retail purchasing prices: theoretical and empirical viewpoints