R
Ruben R. Rosencrantz
Researcher at Fraunhofer Society
Publications - 28
Citations - 413
Ruben R. Rosencrantz is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Glycopolymer & Chemistry. The author has an hindex of 11, co-authored 23 publications receiving 354 citations. Previous affiliations of Ruben R. Rosencrantz include University of Potsdam & RWTH Aachen University.
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Journal ArticleDOI
Enzymatic glycosylation of multivalent scaffolds
TL;DR: Though there is still a long way until the Nature's ideal of multivalent glycans is achievable in the laboratory, the sketched pathways to multivalent glycostructures open tremendous possibilities for the future glycobiological research.
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Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases
Claudia Rech,Ruben R. Rosencrantz,Karel Křenek,Helena Pelantová,Pavla Bojarová,Christiane E. Römer,Franz-Georg Hanisch,Vladimír Křen,Lothar Elling +8 more
TL;DR: An optimized poly-LacNAc synthesis by the combination of two glycosyltransferases and a uridine-diphospho-glucose/N-acetylglucosamine 4′-epimerase as one-pot strategy resulting in long poly-N-acetyllactosamine glycans with up to six LacNAc units in high yields while minimizing reaction time and product loss.
Journal ArticleDOI
Glycopolymer brushes for specific lectin binding by controlled multivalent presentation of N-acetyllactosamine glycan oligomers.
TL;DR: The multiarrays of the glycopolymer brushes have a large potential as a screening device to define optimal-binding environments of specific lectins or as new simplified diagnostic tools for the detection of cancer-related lectins in blood serum.
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Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment
Christiane E. Kupper,Ruben R. Rosencrantz,Birgit Henßen,Helena Pelantová,Stephan Thönes,Anna Drozdová,Vladimír Křen,Lothar Elling +7 more
TL;DR: A set of novel, modified poly-LacNAc oligomers containing terminally and/or internally modified galactose residues were obtained, which can be used for binding studies and various other applications.
Journal ArticleDOI
Evaluating the Thickness of Multivalent Glycopolymer Brushes for Lectin Binding
Jaroslav Lazar,Hyunji Park,Ruben R. Rosencrantz,Alexander Böker,Lothar Elling,Uwe Schnakenberg +5 more
TL;DR: Electrochemical impedance spectroscopy is applied for investigating binding of lectins to multivalent glycopolymer brushes grafted from interdigital gold microelectrodes, revealing distinct dynamics of lectin binding due to changing topology of the brushes.