R
Ruben Van Paemel
Researcher at Ghent University Hospital
Publications - 16
Citations - 589
Ruben Van Paemel is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Liquid biopsy & RNA. The author has an hindex of 6, co-authored 14 publications receiving 144 citations. Previous affiliations of Ruben Van Paemel include Ghent University.
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Journal ArticleDOI
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review.
TL;DR: In this article, the authors performed a systematic review and described the epidemiological, clinical, and prognostic characteristics of 953 PIMS-TS/MIS(-C) cases in 68 records.
Posted ContentDOI
Multisystem inflammatory syndrome in children related to COVID-19: A systematic review
TL;DR: This novel pediatric multisystem hyperinflammatory condition, associated with COVID-19, is characterized by a severe and heterogeneous disease spectrum and despite frequent intensive care interventions, mortality rate was low and short-term outcome favorable.
Journal ArticleDOI
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review
Ruben Van Paemel,Rosalie Vlug,Katleen De Preter,Nadine Van Roy,Franki Speleman,Leen Willems,Tim Lammens,Genevieve Laureys,Gudrun Schleiermacher,Gudrun Schleiermacher,Godelieve A.M. Tytgat,Kathy Astrahantseff,Hedwig E. Deubzer,Bram De Wilde +13 more
TL;DR: Existing analyses of liquid biopsies from children with solid tumors increasingly suggest a potential relevance for molecular diagnostics, prognostic assessment, and therapeutic decision-making as well as enabling detection of pathognomonic and therapeutically relevant genomic alterations.
Journal ArticleDOI
Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles.
Celine Everaert,Hetty Helsmoortel,Anneleen Decock,Eva Hulstaert,Eva Hulstaert,Ruben Van Paemel,Kimberly Verniers,Justine Nuytens,Jasper Anckaert,Nele Nijs,Joeri Tulkens,Bert Dhondt,Bert Dhondt,An Hendrix,Pieter Mestdagh,Jo Vandesompele +15 more
TL;DR: In conclusion, this work is the first to show that the SMARTer method can be used for unbiased unraveling of the complete transcriptome of a wide range of biofluids and their extracellular vesicles.
Journal ArticleDOI
Minimally invasive classification of paediatric solid tumours using reduced representation bisulphite sequencing of cell-free DNA: a proof-of-principle study
Ruben Van Paemel,Ruben Van Paemel,Andries De Koker,Charlotte Vandeputte,Lieke M. J. van Zogchel,Tim Lammens,Tim Lammens,Genevieve Laureys,Genevieve Laureys,Jo Vandesompele,Gudrun Schleiermacher,Mathieu Chicard,Nadine Van Roy,Ales Vicha,Godelieve A.M. Tytgat,Nico Callewaert,Katleen De Preter,Bram De Wilde,Bram De Wilde +18 more
TL;DR: This work provides proof-of-concept of histopathologic classification of paediatric tumours using cell-free reduced representation bisulphite sequencing (cf-RRBS) from retrospectively collected plasma and cerebrospinal fluid samples and determines the correct tumour type in 49 out of 60 samples.