F
Filomeen Haerynck
Researcher at Ghent University Hospital
Publications - 121
Citations - 7626
Filomeen Haerynck is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 24, co-authored 82 publications receiving 4185 citations. Previous affiliations of Filomeen Haerynck include Ghent University.
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Journal ArticleDOI
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Paul Bastard,Paul Bastard,Paul Bastard,Lindsey B. Rosen,Qian Zhang,Eleftherios Michailidis,Hans-Heinrich Hoffmann,Yu Zhang,Karim Dorgham,Quentin Philippot,Quentin Philippot,Jérémie Rosain,Jérémie Rosain,Vivien Béziat,Vivien Béziat,Vivien Béziat,Jeremy Manry,Jeremy Manry,Elana Shaw,Liis Haljasmägi,Pärt Peterson,Lazaro Lorenzo,Lazaro Lorenzo,Lucy Bizien,Lucy Bizien,Sophie Trouillet-Assant,Kerry Dobbs,Adriana Almeida de Jesus,Alexandre Belot,Anne Kallaste,Emilie Catherinot,Yacine Tandjaoui-Lambiotte,Jérémie Le Pen,Gaspard Kerner,Gaspard Kerner,Benedetta Bigio,Yoann Seeleuthner,Yoann Seeleuthner,Rui Yang,Alexandre Bolze,András N Spaan,András N Spaan,Ottavia M. Delmonte,Michael S. Abers,Alessandro Aiuti,Giorgio Casari,Vito Lampasona,Lorenzo Piemonti,Fabio Ciceri,Kaya Bilguvar,Richard P. Lifton,Richard P. Lifton,Marc Vasse,David M. Smadja,Mélanie Migaud,Mélanie Migaud,Jérôme Hadjadj,Benjamin Terrier,Darragh Duffy,Lluis Quintana-Murci,Lluis Quintana-Murci,Diederik van de Beek,Lucie Roussel,Donald C. Vinh,Stuart G. Tangye,Stuart G. Tangye,Filomeen Haerynck,David Dalmau,Javier Martinez-Picado,Javier Martinez-Picado,Petter Brodin,Petter Brodin,Michel C. Nussenzweig,Michel C. Nussenzweig,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Carlos Rodríguez-Gallego,Guillaume Vogt,Trine H. Mogensen,Trine H. Mogensen,Andrew J. Oler,Jingwen Gu,Peter D. Burbelo,Jeffrey I. Cohen,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Patrick Rossignol,Julien Mayaux,Frédéric Rieux-Laucat,Eystein S. Husebye,Eystein S. Husebye,Eystein S. Husebye,Francesca Fusco,Matilde Valeria Ursini,Luisa Imberti,Alessandra Sottini,Simone Paghera,Eugenia Quiros-Roldan,Camillo Rossi,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Xavier Duval,Jade Ghosn,Hgid Lab,Covid Clinicians,Covid-Storm Clinicians§,CoV-Contact Cohort§,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Amsterdam Umc Covid Biobank,Covid Human Genetic Effort,John S. Tsang,Raphaela Goldbach-Mansky,Kai Kisand,Michail S. Lionakis,Anne Puel,Anne Puel,Anne Puel,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Steven M. Holland,Guy Gorochov,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Charles M. Rice,Aurélie Cobat,Aurélie Cobat,Aurélie Cobat,Luigi D. Notarangelo,Laurent Abel,Laurent Abel,Laurent Abel,Helen C. Su,Jean-Laurent Casanova +140 more
TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
Journal ArticleDOI
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Qian Zhang,Paul Bastard,Paul Bastard,Zhiyong Liu,Jérémie Le Pen,Marcela Moncada-Vélez,Jie Chen,Masato Ogishi,Ira K. D. Sabli,Stephanie Hodeib,Cecilia B. Korol,Jérémie Rosain,Jérémie Rosain,Kaya Bilguvar,Junqiang Ye,Alexandre Bolze,Benedetta Bigio,Rui Yang,Andrés Augusto Arias,Andrés Augusto Arias,Qinhua Zhou,Yu Zhang,Fanny Onodi,Sarantis Korniotis,Léa Karpf,Quentin Philippot,Quentin Philippot,Marwa Chbihi,Marwa Chbihi,Lucie Bonnet-Madin,Karim Dorgham,Nikaïa Smith,William M. Schneider,Brandon S. Razooky,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Leen Moens,Ji Eun Han,Lazaro Lorenzo,Lazaro Lorenzo,Lucy Bizien,Lucy Bizien,Philip Meade,Anna-Lena Neehus,Anna-Lena Neehus,Aileen Camille Ugurbil,Aurélien Corneau,Gaspard Kerner,Gaspard Kerner,Peng Zhang,Franck Rapaport,Yoann Seeleuthner,Yoann Seeleuthner,Jeremy Manry,Jeremy Manry,Cécile Masson,Yohann Schmitt,Agatha Schlüter,Tom Le Voyer,Tom Le Voyer,Taushif Khan,Juan Li,Jacques Fellay,Jacques Fellay,Lucie Roussel,Mohammad Shahrooei,Mohammed F. Alosaimi,Davood Mansouri,Haya Al-Saud,Fahd Al-Mulla,Feras M. Almourfi,Saleh Al-Muhsen,Fahad Alsohime,Saeed Al Turki,Rana Hasanato,Diederik van de Beek,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Luisa Imberti,Alessandra Sottini,Simone Paghera,Eugenia Quiros-Roldan,Camillo Rossi,Andrew J. Oler,Miranda F. Tompkins,Camille Alba,Isabelle Vandernoot,Jean-Christophe Goffard,Guillaume Smits,Isabelle Migeotte,Filomeen Haerynck,Pere Soler-Palacín,Andrea Martín-Nalda,Roger Colobran,Pierre-Emmanuel Morange,Sevgi Keles,Fatma Çölkesen,Tayfun Ozcelik,Kadriye Kart Yaşar,Sevtap Şenoğlu,Şemsi Nur Karabela,Carlos Rodríguez-Gallego,Giuseppe Novelli,Sami Hraiech,Yacine Tandjaoui-Lambiotte,Xavier Duval,Xavier Duval,Cédric Laouénan,Cédric Laouénan,Covid-Storm Clinicians§,Covid Clinicians,CoV-Contact Cohort§,CoV-Contact Cohort§,Amsterdam Umc Covid Biobank,Covid Human Genetic Effort,Niaid-Usuhs,Niaid-Usuhs,Niaid-Usuhs,Andrew L. Snow,Clifton L. Dalgard,Joshua D. Milner,Donald C. Vinh,Donald C. Vinh,Trine H. Mogensen,Trine H. Mogensen,Nico Marr,András N Spaan,András N Spaan,András N Spaan,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Stéphanie Boisson-Dupuis,Jacinta Bustamante,Jacinta Bustamante,Jacinta Bustamante,Anne Puel,Michael J. Ciancanelli,Isabelle Meyts,Tom Maniatis,Vassili Soumelis,Ali Amara,Ali Amara,Michel C. Nussenzweig,Adolfo García-Sastre,Florian Krammer,Aurora Pujol,Darragh Duffy,Darragh Duffy,Richard P. Lifton,Richard P. Lifton,Richard P. Lifton,Shen-Ying Zhang,Guy Gorochov,Guy Gorochov,Guy Gorochov,Vivien Béziat,Vivien Béziat,Vivien Béziat,Emmanuelle Jouanguy,Vanessa Sancho-Shimizu,Charles M. Rice,Charles M. Rice,Charles M. Rice,Laurent Abel,Luigi D. Notarangelo,Luigi D. Notarangelo,Luigi D. Notarangelo,Aurélie Cobat,Helen C. Su,Jean-Laurent Casanova +172 more
TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.
Journal ArticleDOI
Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries
Ludovic de Beaucoudrey,Arina Samarina,Arina Samarina,Arina Samarina,Jacinta Bustamante,Jacinta Bustamante,Aurélie Cobat,Aurélie Cobat,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Jacqueline Feinberg,Saleh Al-Muhsen,Lucile Janniere,Yoann Rose,Maylis de Suremain,Xiao-Fei Kong,Orchidée Filipe-Santos,Ariane Chapgier,Capucine Picard,Alain Fischer,Figen Dogu,Aydan Ikinciogullari,Gonul Tanir,Sami Al-Hajjar,Suliman Al-Jumaah,Husn H. Frayha,Zobaida Alsum,Sulaiman Al-Ajaji,Abdullah A. Alangari,Abdulaziz Al-Ghonaium,Parisa Adimi,Davood Mansouri,Imen Ben-Mustapha,Judith Yancoski,Ben-Zion Garty,Carlos Rodríguez-Gallego,Isabel Caragol,Necil Kutukculer,Dinakantha S. Kumararatne,Smita Y. Patel,Rainer Doffinger,Andrew Exley,Olle Jeppsson,Janine Reichenbach,David Nadal,Yaryna Boyko,Barbara Pietrucha,Suzanne T. Anderson,Michael Levin,Liliane Schandené,Kinda Schepers,André Efira,Françoise Mascart,Masao Matsuoka,Tatsunori Sakai,Claire-Anne Siegrist,Klara Frecerova,Renate Blüetters-Sawatzki,Jutta Bernhöft,Joachim Freihorst,Ulrich Baumann,Darko Richter,Filomeen Haerynck,Frans De Baets,Vas Novelli,David A. Lammas,Christiane Vermylen,David Tuerlinckx,Chris Nieuwhof,Małgorzata Pac,Walther H. Haas,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Jacob Levy,Revathi Raj,Aileen C. Cohen,David B. Lewis,Steven M. Holland,Kuender D Yang,Xiaochuan Wang,Xiaohong Wang,Li-Ping Jiang,Xi-qiang Yang,Chaomin Zhu,Yuanyuan Xie,Pamela Pui Wah Lee,Koon Wing Chan,Tong-Xin Chen,Gabriela Castro,Ivelisse Natera,Ana Codoceo,Alejandra King,Liliana Bezrodnik,Daniela Di Giovani,María Isabel Gaillard,Dewton Moraes-Vasconcelos,Anete Sevciovic Grumach,Alberto José da Silva Duarte,Ruth Aldana,Francisco J. Espinosa-Rosales,Mohammed Bejaoui,Ahmed Aziz Bousfiha,Jamila El Baghdadi,Namik Ozbek,Guzide Aksu,Melike Keser,Ayper Somer,Nevin Hatipoğlu,Cigdem Aydogmus,Suna Asilsoy,Yildiz Camcioglu,Saniye Gülle,Tuba Turul Ozgur,Meteran Ozen,Matías Oleastro,Andrea Bernasconi,Setareh Mamishi,Nima Parvaneh,Sergio D. Rosenzweig,Ridha Barbouche,Sigifredo Pedraza,Yu-Lung Lau,Mohammad S. Ehlayel,Claire Fieschi,Laurent Abel,Ozden Sanal,Jean-Laurent Casanova +127 more
TL;DR: An international survey of 141 patients from 102 kindreds in 30 countries found that IL-12R&bgr;1 deficiency has higher clinical penetrance, broader susceptibility to infections, and less favorable outcome than previously thought.
Journal ArticleDOI
Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP-deficiency) versus type 2 (XLP-2/XIAP-deficiency)
Jana Pachlopnik Schmid,Jana Pachlopnik Schmid,Danielle Canioni,Despina Moshous,Despina Moshous,Fabien Touzot,Nizar Mahlaoui,Fabian Hauck,Fabian Hauck,Hirokazu Kanegane,Eduardo López-Granados,Ester Mejstrikova,Isabelle Pellier,Lionel Galicier,Claire Galambrun,Vincent Barlogis,Pierre Bordigoni,Alain Fourmaintraux,Mohamed Hamidou,Alain Dabadie,Françoise Le Deist,Filomeen Haerynck,Marie Ouachée-Chardin,Pierre-Simon Rohrlich,Jean-Louis Stephan,Christelle Lenoir,Stephanie Rigaud,Stephanie Rigaud,Nathalie Lambert,Michèle Milili,Claudin Schiff,Helen Chapel,Capucine Picard,Capucine Picard,Geneviève de Saint Basile,Geneviève de Saint Basile,Stéphane Blanche,Alain Fischer,Alain Fischer,Sylvain Latour,Sylvain Latour +40 more
TL;DR: This first phenotypic comparison of XLP subtypes should help to improve the diagnosis and the care of patients with XLP conditions.
Journal ArticleDOI
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review.
TL;DR: In this article, the authors performed a systematic review and described the epidemiological, clinical, and prognostic characteristics of 953 PIMS-TS/MIS(-C) cases in 68 records.