R
Rudolf Schmid
Researcher at Hoffmann-La Roche
Publications - 76
Citations - 1321
Rudolf Schmid is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alkyl & Alkoxy group. The author has an hindex of 15, co-authored 76 publications receiving 1290 citations.
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Journal ArticleDOI
New developments in enantioselective hydrogenation
Rudolf Schmid,Emil Albin Broger,Marco Cereghetti,Yvo Crameri,Joseph Foricher,Michel Lalonde,R. K. Müller,M. Scalone,G. Schoettel,Ulrich Zutter +9 more
TL;DR: A broad variety of atropisomeric biphenyl diphosphines have been synthesized via optically active 6,6'-dimethoxybiphenyl-2,2'-diyl-bis(diphhenyl phosphonates), -bis@hosphonic dichlorides, -bis(phosphonous dichloride) and-bis@rimary diphophosphines as discussed by the authors.
Journal ArticleDOI
Axially Dissymmetric Diphosphines in the Biphenyl Series: Synthesis of (6,6′‐Dimethoxybiphenyl‐2,2′‐diyl)bis(diphenylphosphine)(‘MeO‐BIPHEP’) and Analogues via an ortho‐Lithiation/Iodination Ullmann‐Reaction Approach
TL;DR: In this paper, axially dissymmetric diphosphines (R)- and (S)-(6,6′-dimethoxybiphenyl-2,2′-diyl)bis(diphenymethylphosphine) ((R)-and(S)-5a; ‘MeO-BIPHEP’) and the analogues (R-and (S-5b and 5c) have been synthesized in enantiomerically pure form.
Journal ArticleDOI
Axially dissymmetric bis(triaryl)phosphines in the biphenyl series: synthesis of (6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine) (BIPHEMP) and analogues, and their use in Rh(I)-catalyzed asymmetric isomerizations of N,N-diethylnerylamine
TL;DR: The axially dissymmetric diphosphines (−)-(R)- and (+)-(S)-(6-6′-dimethylbiphenyl-2,2′-diyl)bis(diphosphine) as mentioned in this paper have been synthesized and resolved into optically pure (R)-and (S)-enantiomers via complexation with di-μ-chlorob is {(R]-2-[1-(dimethylamino)ethyl]pheny-CN}dipalladium(II) ((R)-18)
Journal ArticleDOI
Piperidine renin inhibitors: from leads to drug candidates.
Maerki Hans-Peter,Alfred Binggeli,Beate Bittner,V Bohner-Lang,Volker Breu,Daniel Bur,Philippe Coassolo,Jean-Paul Clozel,Allan D'Arcy,H Doebeli,Walter Fischli,Christoph Funk,Joseph Foricher,Thomas Giller,Fiona Grüninger,Alberto Guenzi,Rolf Güller,Thomas Hartung,Greg Hirth,Christian Jenny,Manfred Kansy,Uwe Klinkhammer,Thierry Lavé,Bruno Lohri,Friedrich C. Luft,E M Mervaala,Dominik N. Müller,Marcel Muller,Francois Montavon,Christian Oefner,C Qiu,Andreas Reichel,P Sanwald-Ducray,Michelangelo Scalone,Michael Schleimer,Rudolf Schmid,Heinz Stadler,A. Treiber,Olivier Valdenaire,Eric Vieira,Pius Waldmeier,R Wiegand-Chou,Maurice Wilhelm,Wolfgang Wostl,Manfred Zell,R Zell +45 more
TL;DR: Treatment of chronic renal failure patients with a renin inhibitor might result in a significant improvement of the disease status, and two candidate compounds 14 and 23 display potent and long-lasting blood pressure lowering effects.
Journal ArticleDOI
New amidophosphine-phosphinites (tLANOPs) as chiral ligands for asymmetric hydrogenation reactions
TL;DR: The tLANOP ligands derived from the chiral hydroxy amide (R)- or (S)-2-hydroxy-3,3,N-trimethylbutyramide have been prepared in 48-83% yield.