D
Dominik N. Müller
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 433
Citations - 27567
Dominik N. Müller is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 82, co-authored 410 publications receiving 23229 citations. Previous affiliations of Dominik N. Müller include University of Erlangen-Nuremberg & Hannover Medical School.
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Journal ArticleDOI
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Markus Kleinewietfeld,Arndt Manzel,Arndt Manzel,Jens Titze,Jens Titze,Heda Kvakan,Nir Yosef,Ralf A. Linker,Dominik N. Müller,Dominik N. Müller,David A. Hafler,David A. Hafler +11 more
TL;DR: It is shown that increased salt concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells, which display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2.
Journal ArticleDOI
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Katrin Kierdorf,Daniel Erny,Tobias Goldmann,Victor Sander,Christian Schulz,Elisa Gomez Perdiguero,Peter Wieghofer,Annette Heinrich,Pia Riemke,Christoph Hölscher,Dominik N. Müller,Bruno Luckow,Thomas Brocker,Katharina Debowski,Günter Fritz,Ghislain Opdenakker,Andreas Diefenbach,Knut Biber,Knut Biber,Mathias Heikenwalder,Frederic Geissmann,Frank Rosenbauer,Marco Prinz +22 more
TL;DR: It is found that mouse microglia were derived from primitive c-kit+ erythromyeloid precursors that were detected in the yolk sac as early as 8 d post conception and microgliogenesis was not only dependent on the transcription factor Pu.1, but also required Irf8, which was vital for the development of the A2 population, whereas Myb, Id2, Batf3 and Klf4 were not required.
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
Agnes Machnik,Wolfgang Neuhofer,Jonathan Jantsch,Anke Dahlmann,Tuomas Tammela,Katharina Machura,Joon-Keun Park,F. X. Beck,Dominik N. Müller,Wolfgang Derer,Jennifer Goss,Agata Ziomber,Peter Dietsch,Hubertus Wagner,Nico van Rooijen,Armin Kurtz,Karl F. Hilgers,Kari Alitalo,Kai-Uwe Eckardt,Friedrich C. Luft,Dontscho Kerjaschki,Jens Titze +21 more
TL;DR: It is shown that a high-salt diet in rats leads to interstitial hypertonic Na+ accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network and VEGFC is identified as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension.
Journal ArticleDOI
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.
Duska Dragun,Dominik N. Müller,Jan Hinrich Bräsen,Lutz Fritsche,Melina Nieminen-Kelhä,Ralf Dechend,Ulrich Kintscher,Birgit Rudolph,Johan Hoebeke,Diana Eckert,Istvan Mazak,Ralph Plehm,Constanze Schönemann,Thomas Unger,Klemens Budde,Hans-Hellmut Neumayer,Friedrich C. Luft,Gerd Wallukat +17 more
TL;DR: A non-HLA, AT1-receptor-mediated pathway may contribute to refractory vascular rejection, and affected patients might benefit from removal of At1- receptor antibodies or from pharmacologic blockade of AT1 receptors.
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Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine
Aiden Haghikia,Stefanie Jörg,Alexander Duscha,Johannes Berg,Arndt Manzel,Anne Waschbisch,Anna Hammer,De-Hyung Lee,Caroline May,Nicola Wilck,András Balogh,Annika I. Ostermann,Nils Helge Schebb,Denis A. Akkad,Diana A. Grohme,Markus Kleinewietfeld,Stefan Kempa,Jan Thöne,Seray Demir,Dominik N. Müller,Ralf Gold,Ralf A. Linker +21 more
TL;DR: Dietary long-chain fatty acids enhanced differentiation and proliferation of T helper 1 and/or Th17 cells and impaired their intestinal sequestration via p38-MAPK pathway and dietary short-chain FAs expanded gut T regulatory (Treg) cells by suppression of the JNK1 and p38 pathway.