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Rudy Leibel
Researcher at Columbia University
Publications - 4
Citations - 2043
Rudy Leibel is an academic researcher from Columbia University. The author has contributed to research in topics: Induced pluripotent stem cell & Insulin receptor. The author has an hindex of 3, co-authored 4 publications receiving 1960 citations.
Papers
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Journal ArticleDOI
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
John T. Dimos,Kit T. Rodolfa,Kathy K. Niakan,Laurin M. Weisenthal,Hiroshi Mitsumoto,Wendy K. Chung,Wendy K. Chung,Gist F. Croft,Genevieve Saphier,Rudy Leibel,Robin Goland,Hynek Wichterle,Christopher E. Henderson,Kevin Eggan +13 more
TL;DR: Induced pluripotent stem cells are generated from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.
Journal ArticleDOI
Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations
Marisa Censani,Rushika Conroy,Liyong Deng,Sharon E. Oberfield,Donald J. McMahon,Jeffrey L. Zitsman,Rudy Leibel,Wendy K. Chung,Ilene Fennoy +8 more
TL;DR: To determine the frequency of Melanocortin 4 Receptor (MC4R) mutations in morbidly obese adolescents undergoing bariatric surgery and compare weight loss outcomes in patients with and without mutations, a genome-wide association study is conducted.
Patent
Er stress relievers in beta cell protection
TL;DR: In this article, the authors used small molecules to relieve endoplasmic reticulum (ER) stress, leading to increased insulin production in beta cells and improved insulin secretion.
Posted ContentDOI
Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons
Liheng Wang,Yang Liu,George Stratigopoulos,Sunil K Panigrahi,Lina Sui,Charles A. LeDuc,Hannah J. Glover,M. C. De Rosa,Lisa Cole Burnett,Damian J. Williams,Linshan Shang,Linshan Shang,Robin Goland,Stephen H. Tsang,Sharon L. Wardlaw,Dieter Egli,Dieter Egli,Dieter Egli,Deyou Zheng,Claudia A. Doege,Rudy Leibel +20 more
TL;DR: A cellular model of BBS using induced pluripotent stem cell (iPSCs)-derived hypothalamic arcuate-like neurons is developed and insights into the anatomic and functional mechanisms by which components of the BBsome in CNS primary cilia mediate effects on energy homeostasis are provided.