H
Hynek Wichterle
Researcher at Columbia University
Publications - 101
Citations - 15247
Hynek Wichterle is an academic researcher from Columbia University. The author has contributed to research in topics: Motor neuron & Embryonic stem cell. The author has an hindex of 45, co-authored 93 publications receiving 14086 citations. Previous affiliations of Hynek Wichterle include Rockefeller University & New York University.
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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
John T. Dimos,Kit T. Rodolfa,Kathy K. Niakan,Laurin M. Weisenthal,Hiroshi Mitsumoto,Wendy K. Chung,Wendy K. Chung,Gist F. Croft,Genevieve Saphier,Rudy Leibel,Robin Goland,Hynek Wichterle,Christopher E. Henderson,Kevin Eggan +13 more
TL;DR: Induced pluripotent stem cells are generated from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.
Journal ArticleDOI
Directed Differentiation of Embryonic Stem Cells into Motor Neurons
TL;DR: It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.
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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Makiko Nagai,Diane B. Re,Tetsuya Nagata,Alcmène Chalazonitis,Thomas M. Jessell,Hynek Wichterle,Serge Przedborski +6 more
TL;DR: It is shown that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration, and indicates that astrocytes may play a role in the specific degeneration of spinal motor neuron neurons in ALS.
Journal ArticleDOI
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Kazunobu Sawamoto,Hynek Wichterle,Oscar Gonzalez-Perez,Jeremy A. Cholfin,Masayuki Yamada,Nathalie Spassky,Noel S. Murcia,José Manuel García-Verdugo,Oscar Marín,John L.R. Rubenstein,Marc Tessier-Lavigne,Hideyuki Okano,Arturo Alvarez-Buylla +12 more
TL;DR: It is shown that neuroblast migration parallels cerebrospinal fluid (CSF) flow, and results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Journal ArticleDOI
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.
Hynek Wichterle,Daniel H. Turnbull,Daniel H. Turnbull,Susana Vaz Nery,Susana Vaz Nery,Gord Fishell,Gord Fishell,Arturo Alvarez-Buylla,Arturo Alvarez-Buylla,Arturo Alvarez-Buylla +9 more
TL;DR: It is demonstrated that LGE and MGE cells migrate along different routes to populate distinct regions in the developing brain, and it is shown that the MGE is a major source of neurons migrating dorsally and invading the developing neocortex.