R
Ruihan Zhang
Researcher at Yunnan University
Publications - 68
Citations - 1094
Ruihan Zhang is an academic researcher from Yunnan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 12, co-authored 42 publications receiving 677 citations. Previous affiliations of Ruihan Zhang include German Cancer Research Center & Chinese Academy of Sciences.
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Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
Yi-Ming Li,Rong-Hua Luo,Liu-Meng Yang,Si-Ming Huang,Sui-Yuan Li,Yu-Gui Zheng,Dong-Xuan Ni,Yi-Man Cui,Xing-Jie Zhang,Xiao-Li Li,Ruihan Zhang,E Tang,Hongbin Zhang,Yong-Tang Zheng,Yan-Ping He,Wei-Lie Xiao +15 more
TL;DR: The study which offered the preliminary structure-activity relationships and modeling studies of these new compounds has provided the valuable avenues for future molecular optimization.
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Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects
Xue-Wen Wu,Qi Wang,Qing Li,Yi-Man Cui,Yu-Kun Pu,Qiang-Qiang Shi,De-Wen Bi,Jing-Jing Zhang,Ruihan Zhang,Xiao-Li Li,Zhang Xingjie,Zhang Xingjie,Wei-Lie Xiao +12 more
TL;DR: Four new diterpenoids, rubellawus A–D (1–4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella and their structures were elucidated by various spectroscopic analysis.
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The bioactive limonoids from Toona ciliate as NLRP3 inflammasome inhibitors
Qiang-Qiang Shi,Ting-Ting Wang,Xing-Jie Zhang,Yu-Kun Pu,Xu Ji,Xiao-Li Li,Xiao-Chang Dai,Muhammad Aurang Zeb,Ruihan Zhang,Wei-Lie Xiao +9 more
TL;DR: Compound 4 could provide support for the medical application of T. ciliate as natural inhibitors of NLRP3 inflammasome and blocked cell pyroptosis.
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Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents.
Dong-Xuan Ni,Qi Wang,Yi-Ming Li,Yi-Man Cui,Tian-Ze Shen,Xiao-Li Li,Han-Dong Sun,Xing-Jie Zhang,Ruihan Zhang,Wei-Lie Xiao +9 more
TL;DR: In this paper, triterpenoids nigranoic acid and manwuweizic acid (MA) were identified as HDAC inhibitors through docking-based virtual screening and enzymatic activity assay.
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Design, synthesis and anti-breast cancer evaluation of biaryl pyridine analogues as potent RSK inhibitors.
Yidong Cui,Wei Li,Tianze Shen,Yongxing Tao,Biao Liu,Xiaoli Li,Ruihan Zhang,Dewei Jiang,Wei-Lie Xiao +8 more
TL;DR: In this article , 50 pyridyl biaryl derivatives were designed and synthesized with LJH685 as the lead compound and their anti-tumor ability was tested.