R
Ruihan Zhang
Researcher at Yunnan University
Publications - 68
Citations - 1094
Ruihan Zhang is an academic researcher from Yunnan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 12, co-authored 42 publications receiving 677 citations. Previous affiliations of Ruihan Zhang include German Cancer Research Center & Chinese Academy of Sciences.
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Journal ArticleDOI
Euphopias A-C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.02,7]tridecane and Tetracyclo[11.3.0.02,10.03,7]hexadecane Cores from Euphorbia helioscopia.
Qiang-Qiang Shi,Xing-Jie Zhang,Ting-Ting Wang,Qi Wang,Tian-Tian Sun,Muhammad Amin,Ruihan Zhang,Xiao-Li Li,Wei-Lie Xiao +8 more
TL;DR: A mechanistic study revealed that 2 could ameliorate mitochondria damage, thereby interrupting NLRP3 inflammasome activation, and could significantly inhibit NLRP1 inflammaome activation and block NLRP2 inflamMasome-induced pyroptosis.
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Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination.
Xibao Zhao,Xibao Zhao,Debing Pu,Debing Pu,Zizhao Zhao,Huihui Zhu,Hongrui Li,Hongrui Li,Yaping Shen,Xing-Jie Zhang,Ruihan Zhang,Jianzhong Shen,Wei-Lie Xiao,Wei-Lie Xiao,Weilin Chen,Weilin Chen +15 more
TL;DR: Tevincenone F is a highly effective natural compound to suppress LPS-induced inflammation by attenuating K63-linked ubiquitination of NEMO, highlighting that Teuvincenones F may be a potential new anti-inflammatory drug for the treatment of inflammatory and NLRP3 inflammasome-driven diseases.
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Chemical Space and Biological Target Network of Anti-Inflammatory Natural Products.
TL;DR: Anti-inflammatory NPs provide a good library for the screening of target-based leads or fragment-based drug design, and elucidation of their biological targets is fundamental for either a specific single-target or multitarget drug development strategy.
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Triterpenoids from Ganoderma gibbosum : A Class of Sensitizers of FLC-Resistant Candida albicans to Fluconazole
De-Bing Pu,Xiao-Ning Li,Jing Lin,Ruihan Zhang,Ting Luo,Yuan Wang,Junbo Gao,Muhammad Aurang Zeb,Xing-Jie Zhang,Xiao-Li Li,Ruirui Wang,Wei-Lie Xiao +11 more
TL;DR: Results show that the calculated NMR with DP4+ analysis could not reliably establish the overall spatial configuration of molecules possessing independent and free-rotational stereoclusters, and all these compounds significantly increased the sensitivity of fluconazole (FLC)-resistant C. albicans to FLC.
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Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.
Zhongjie Liang,Jing Ai,Xiao Ding,Xia Peng,Dengyou Zhang,Ruihan Zhang,Ying Wang,Fang Liu,Mingyue Zheng,Hualiang Jiang,Hong Liu,Meiyu Geng,Cheng Luo +12 more
TL;DR: The dual roles of compound 2a demonstrate the potency of anthraquinone derivatives and provide a new design solution for the c-Met kinase signaling pathway.