R
Ruihua Wang
Researcher at Johns Hopkins University
Publications - 20
Citations - 591
Ruihua Wang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 12, co-authored 18 publications receiving 511 citations. Previous affiliations of Ruihua Wang include Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Infection and Inflammation in Schizophrenia and Bipolar Disorder: A Genome Wide Study for Interactions with Genetic Variation
Dimitrios Avramopoulos,Brad D. Pearce,John A. McGrath,Paula S. Wolyniec,Ruihua Wang,Nicole Eckart,Alexandros Hatzimanolis,Fernando S. Goes,Gerald Nestadt,Jennifer G. Mulle,Karen Coneely,Myfanwy Hopkins,Ingo Ruczinski,Robert H. Yolken,Ann E. Pulver +14 more
TL;DR: The results support that inflammatory processes and infection may modify the risk for psychosis and suggest that the genotype at SZ-associated HLA loci modifies the effect of these variables on the risk to develop SZ.
Journal ArticleDOI
Functional Characterization of Schizophrenia-Associated Variation in CACNA1C.
Nicole Eckart,Qifeng Song,Rebecca Yang,Ruihua Wang,Heng Zhu,Andrew S. McCallion,Dimitrios Avramopoulos +6 more
TL;DR: The results elucidate the pathogenic relevance of one of the best-supported risk loci for schizophrenia and bipolar disorder and show interaction of the disease-associated region including the 16 SNPs with the CACNA1C promoter and other potential regulatory regions.
Journal ArticleDOI
Gene expression reveals overlap between normal aging and Alzheimer's disease genes.
TL;DR: There is a highly significant overlap between genes changing expression with age and those changing in AD, and it is observed that those changes are most often in the same direction.
Journal ArticleDOI
Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood
Alex Hatzimanolis,Pallav Bhatnagar,Anna Moes,Ruihua Wang,Panos Roussos,Panos Bitsios,Costas N. Stefanis,Ann E. Pulver,Dan E. Arking,Nikolaos Smyrnis,Nicholas C. Stefanis,Dimitrios Avramopoulos +11 more
TL;DR: Results imply that common genetic variation explains some of the variability in neurocognitive functioning among young adults, particularly WM, and provide supportive evidence that increased SZ genetic risk predicts neuroc cognitive fluctuations in the general population.
Journal ArticleDOI
Alzheimer's risk variants in the clusterin gene are associated with alternative splicing
TL;DR: A biological mechanism for the genetic association of CLU with AD risk is suggested and it is indicated that rs9331888 is one of the functional DNA variants underlying this association.