A
Ann E. Pulver
Researcher at Johns Hopkins University School of Medicine
Publications - 134
Citations - 24834
Ann E. Pulver is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 56, co-authored 130 publications receiving 20900 citations. Previous affiliations of Ann E. Pulver include LDS Hospital & Howard Hughes Medical Institute.
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Journal ArticleDOI
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Journal ArticleDOI
Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke,Alan R. Sanders,Kenneth S. Kendler,Douglas F. Levinson,Pamela Sklar,Pamela Sklar,Peter Holmans,Danyu Lin,Jubao Duan,Roel A. Ophoff,Roel A. Ophoff,Ole A. Andreassen,Edward M. Scolnick,Sven Cichon,David St Clair,Aiden Corvin,Hugh Gurling,Thomas Werge,Dan Rujescu,Douglas Blackwood,Carlos N. Pato,Anil K. Malhotra,Anil K. Malhotra,Shaun Purcell,Frank Dudbridge,Benjamin M. Neale,Lizzy Rossin,Peter M. Visscher,Danielle Posthuma,Douglas M. Ruderfer,Ayman H. Fanous,Ayman H. Fanous,Ayman H. Fanous,Hreinn Stefansson,Stacy Steinberg,Bryan J. Mowry,Vera Golimbet,Marc De Hert,Erik G. Jönsson,István Bitter,Olli Pietiläinen,David A. Collier,Sarah Tosato,Ingrid Agartz,Margot Albus,Madeline Alexander,Richard Amdur,Richard Amdur,Farooq Amin,Farooq Amin,Nicholas Bass,Sarah E. Bergen,Donald W. Black,Anders D. Børglum,Matthew A. Brown,Richard Bruggeman,Nancy G. Buccola,William Byerley,Wiepke Cahn,Rita M. Cantor,Vaughan J. Carr,Stanley V. Catts,Khalid Choudhury,C. Robert Cloninger,Paul Cormican,Nicholas John Craddock,Patrick Danoy,Susmita Datta,Lieuwe de Haan,Ditte Demontis,Dimitris Dikeos,Srdjan Djurovic,Peter Donnelly,Gary Donohoe,L. Duong,Sarah Dwyer,Anders Fink-Jensen,Robert Freedman,Nelson B. Freimer,Marion Friedl,Lyudmila Georgieva,Ina Giegling,Michael Gill,Birte Glenthøj,Stephanie Godard,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Annette M. Hartmann,Frans Henskens,David M. Hougaard,Christina M. Hultman,Andres Ingason,Assen Jablensky,Klaus D. Jakobsen,M. Jay,Gesche Jürgens,René S. Kahn,Matthew C. Keller,Gunter Kenis,Elaine Kenny,Yunjung Kim,George Kirov,H. Konnerth,Bettina Konte,Lydia Krabbendam,Robert Krasucki,Virginia K. Lasseter,Claudine Laurent,Jacob Lawrence,Todd Lencz,Todd Lencz,F. Bernard Lerer,Kung Yee Liang,Paul Lichtenstein,Jeffrey A. Lieberman,Don H. Linszen,Jouko Lönnqvist,Carmel M. Loughland,Alan W Maclean,Brion S. Maher,Wolfgang Maier,J. Mallet,P. Malloy,Manuel Mattheisen,Morten Mattingsdal,Kevin A. McGhee,John J. McGrath,Andrew M. McIntosh,Duncan E. McLean,Andrew McQuillin,Ingrid Melle,Patricia T. Michie,Vihra Milanova,Derek W. Morris,Ole Mors,Preben Bo Mortensen,Valentina Moskvina,Pierandrea Muglia,Inez Myin-Germeys,Deborah A. Nertney,Gerald Nestadt,Jimmi Nielsen,Ivan Nikolov,Merete Nordentoft,Nadine Norton,Markus M. Nöthen,Colm O'Dushlaine,Ann Olincy,Line Olsen,F. Anthony O'Neill,Torben F. Ørntoft,Michael John Owen,Christos Pantelis,George N. Papadimitriou,Michele T. Pato,Leena Peltonen,Leena Peltonen,Hannes Petursson,Ben S. Pickard,Jonathan Pimm,Ann E. Pulver,Vinay Puri,Digby Quested,Emma M. Quinn,Henrik B. Rasmussen,János Réthelyi,R. Ribble,Marcella Rietschel,Marcella Rietschel,Brien P. Riley,Mirella Ruggeri,Ulrich Schall,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Sibylle G. Schwab,Rodney J. Scott,Jianxin Shi,Engilbert Sigurdsson,Jeremy M. Silverman,Jeremy M. Silverman,Chris C. A. Spencer,Kari Stefansson,Amy Strange,Eric Strengman,T. Scott Stroup,Jaana Suvisaari,Lars Terenius,Srinivasa Thirumalai,Johan H. Thygesen,Sally Timm,Draga Toncheva,Edwin J. C. G. van den Oord,Jim van Os,Ruud van Winkel,Ruud van Winkel,Jan H. Veldink,Dermot Walsh,August G. Wang,Durk Wiersma,Dieter B. Wildenauer,Hywel Williams,Nigel Williams,Brandon Wormley,Stan Zammit,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan,Mark J. Daly,Pablo V. Gejman +210 more
TL;DR: The authors examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects.
Journal ArticleDOI
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Cathryn M. Lewis,Douglas F. Levinson,Lesley H. Wise,Lynn E. DeLisi,Richard E. Straub,Iiris Hovatta,Nigel Williams,Sibylle G. Schwab,Ann E. Pulver,Stephen V. Faraone,Linda M. Brzustowicz,Linda M. Brzustowicz,Charles A. Kaufmann,David L. Garver,Hugh Gurling,Eva Lindholm,Hilary Coon,Hans W. Moises,William Byerley,Sarah H. Shaw,Andrea Mesén,Robin Sherrington,F. Anthony O'Neill,Dermot Walsh,Kenneth S. Kendler,Jesper Ekelund,Tiina Paunio,Jouko Lönnqvist,Leena Peltonen,Leena Peltonen,Michael Conlon O'Donovan,Michael John Owen,Dieter B. Wildenauer,Wolfgang Maier,Gerald Nestadt,Jean-Louis Blouin,Stylianos E. Antonarakis,Bryan J. Mowry,Jeremy M. Silverman,Raymond R. Crowe,C. Robert Cloninger,Ming T. Tsuang,Dolores Malaspina,Jill M. Harkavy-Friedman,Dragan M. Svrakic,Anne S. Bassett,Jennifer A. Holcomb,Gursharan Kalsi,Andrew McQuillin,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Elena Jazin,Tómas Zoega,Tómas Helgason +54 more
TL;DR: The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
Journal ArticleDOI
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Bjarni J. Vilhjálmsson,Jian Yang,Hilary K. Finucane,Alexander Gusev,Sara Lindström,Stephan Ripke,Giulio Genovese,Po-Ru Loh,Gaurav Bhatia,Ron Do,Tristan J. Hayeck,Hong-Hee Won,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai How Farh,Peter Holmans,Phil Lee,Brendan Bulik-Sullivan,David A. Collier,Hailiang Huang,Tune H. Pers,Ingrid Agartz,E. Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F. C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Paola Giusti-Rodrguez,Stephanie Godard,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Jakob Grove,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Joel N. Hirschhorn,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko K. Lnnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,Jacques Mallet,Sara Marsal,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Ole Mors,Preben Bo Mortensen,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietilinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian Schubert,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Sderman,Srinivas Thirumalai,Draga Toncheva,Paul A. Tooney,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Jing Qin Wu,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Anil K. Malhotra,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Bryan J. Mowry,Markus M. Nthen,Roel A. Ophoff,Michael John Owen,A. Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Mark J. Daly,Patrick F. Sullivan,Michael Conlon O'Donovan,Peter Kraft,David J. Hunter,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Laura Baglietto,Sonja I. Berndt,Carl Blomquist,Federico Canzian,Jenny Chang-Claude,Stephen J. Chanock,Laura Crisponi,Kamila Czene,Norbert Dahmen,Isabel dos Santos Silva,Douglas F. Easton,A. Heather Eliassen,Jonine D. Figueroa,Olivia Fletcher,Montserrat Garcia-Closas,Mia M. Gaudet,Lorna Gibson,Christopher A. Haiman,Per Hall,Aditi Hazra,Rebecca Hein,Brian E. Henderson,Albert Hofman,John L. Hopper,Astrid Irwanto,Mattias Johansson,Rudolf Kaaks,Muhammad G. Kibriya,Peter Lichtner,Eiliv Lund,Enes Makalic,Alfons Meindl,Hanne Meijers-Heijboer,Bertram Müller-Myhsok,Taru A. Muranen,Heli Nevanlinna,Petra H.M. Peeters,Julian Peto,Ross L. Prentice,Nazneen Rahman,María José Sánchez,Daniel F. Schmidt,Rita K. Schmutzler,Melissa C. Southey,Rulla M. Tamimi,Ruth C. Travis,Clare Turnbull,André G. Uitterlinden,Rob B. van der Luijt,Quinten Waisfisz,Zhaoming Wang,Alice S. Whittemore,Rose Yang,Wei Zheng,Wei Zheng,Sekar Kathiresan,Michele T. Pato,Carlos N. Pato,E Stahl,Noah Zaitlen,Bogdan Pasaniuc,Gillian M. Belbin,Eimear E. Kenny,Mikkel H. Schierup,Phillip L. De Jager,Nikolaos A. Patsopoulos,Steve McCarroll,Mark J. Daly,Shaun M. Purcell,Daniel I. Chasman,Benjamin M. Neale,Michael E. Goddard,Nick Patterson,Alkes L. Price +394 more
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
Journal ArticleDOI
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Phil Lee,Verneri Anttila,Hyejung Won,Yen-Chen Anne Feng,Jacob Rosenthal,Zhaozhong Zhu,Elliot M. Tucker-Drob,Michel G. Nivard,Andrew D. Grotzinger,Danielle Posthuma,Meg M.-J. Wang,Dongmei Yu,Eli A. Stahl,Raymond K. Walters,Richard Anney,Laramie E. Duncan,Tian Ge,Rolf Adolfsson,Tobias Banaschewski,Sintia Iole Belangero,Edwin H. Cook,Giovanni Coppola,Eske M. Derks,Pieter J. Hoekstra,Jaakko Kaprio,Anna Keski-Rahkonen,George Kirov,George Kirov,Henry R. Kranzler,Jurjen J. Luykx,Luis Augusto Rohde,Clement C. Zai,Esben Agerbo,Maria Arranz,Philip Asherson,Marie Bækvad-Hansen,Gisli Baldursson,Mark A. Bellgrove,Richard A. Belliveau,Jan K. Buitelaar,Christie L. Burton,Jonas Bybjerg-Grauholm,Miquel Casas,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Bru Cormand,Jennifer Crosbie,Søren Dalsgaard,Ditte Demontis,Alysa E. Doyle,Ashley Dumont,Josephine Elia,Jakob Grove,Olafur O Gudmundsson,Jan Haavik,Hakon Hakonarson,Christine Søholm Hansen,Catharina A. Hartman,Ziarih Hawi,Amaia Hervás,David M. Hougaard,Daniel P. Howrigan,Hailiang Huang,Jonna Kuntsi,Kate Langley,Klaus-Peter Lesch,Patrick W. L. Leung,Sandra K. Loo,Joanna Martin,Alicia R. Martin,James J. McGough,Sarah E. Medland,Jennifer L. Moran,Ole Mors,Preben Bo Mortensen,Robert D. Oades,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Triinu Peters,Timothy Poterba,Jesper Buchhave Poulsen,Josep Antoni Ramos-Quiroga,Andreas Reif,Marta Ribasés,Aribert Rothenberger,Paula Rovira,Cristina Sánchez-Mora,F. Kyle Satterstrom,Russell Schachar,María Soler Artigas,Stacy Steinberg,Hreinn Stefansson,Patrick Turley,G. Bragi Walters,Thomas Werge,Tetyana Zayats,Dan E. Arking,Francesco Bettella,Joseph D. Buxbaum,Jane H. Christensen,Ryan L. Collins,Hilary Coon,Silvia De Rubeis,Richard Delorme,Dorothy E. Grice,Thomas Hansen,Peter Holmans,Sigrun Hope,Christina M. Hultman,Lambertus Klei,Christine Ladd-Acosta,Páll Magnússon,Terje Nærland,Mette Nyegaard,Dalila Pinto,Per Qvist,Karola Rehnström,Abraham Reichenberg,Jennifer Reichert,Kathryn Roeder,Guy A. Rouleau,Evald Saemundsen,Stephen Sanders,Sven Sandin,Beate St Pourcain,Kari Stefansson,James S. Sutcliffe,Michael E. Talkowski,Lauren A. Weiss,A. Jeremy Willsey,Ingrid Agartz,Huda Akil,Diego Albani,Martin Alda,Thomas Damm Als,Adebayo Anjorin,Lena Backlund,Nicholas Bass,Michael Bauer,Bernhard T. Baune,Frank Bellivier,Sarah E. Bergen,Wade H. Berrettini,Joanna M. Biernacka,Douglas Blackwood,Erlend Bøen,Monika Budde,William E. Bunney,Margit Burmeister,William Byerley,Enda M. Byrne,Sven Cichon,Toni-Kim Clarke,Jonathan R. I. Coleman,Nicholas John Craddock,David Curtis,Piotr M. Czerski,Anders M. Dale,Nina Dalkner,Udo Dannlowski,Franziska Degenhardt,Arianna Di Florio,Torbjørn Elvsåshagen,Bruno Etain,Sascha B. Fischer,Andreas J. Forstner,Liz Forty,Josef Frank,Mark A. Frye,Janice M. Fullerton,Katrin Gade,Helena Gaspar,Elliot S. Gershon,Michael Gill,Fernando S. Goes,Scott D. Gordon,Katherine Gordon-Smith,Melissa J. Green,Tiffany A. Greenwood,Maria Grigoroiu-Serbanescu,Jose Guzman-Parra,Joanna Hauser,Martin Hautzinger,Urs Heilbronner,Stefan Herms,Per Hoffmann,Dominic Holland,Stéphane Jamain,Ian Jones,Lisa Jones,Radhika Kandaswamy,John R. Kelsoe,James L. Kennedy,Oedegaard Ketil Joachim,Sarah Kittel-Schneider,Manolis Kogevinas,Anna C. Koller,Catharina Lavebratt,Cathryn M. Lewis,Qingqin S. Li,Jolanta Lissowska,Loes M. Olde Loohuis,Susanne Lucae,Anna Maaser,Ulrik Fredrik Malt,Nicholas G. Martin,Lina Martinsson,Susan L. McElroy,Francis J. McMahon,Andrew McQuillin,Ingrid Melle,Andres Metspalu,Vincent Millischer,Philip B. Mitchell,Grant W. Montgomery,Gunnar Morken,Derek W. Morris,Bertram Müller-Myhsok,Niamh Mullins,Richard M. Myers,Caroline M. Nievergelt,Merete Nordentoft,Annelie Nordin Adolfsson,Markus M. Nöthen,Roel A. Ophoff,Michael John Owen,Sara A. Paciga,Carlos N. Pato,Michele T. Pato,Roy H. Perlis,Amy Perry,James B. Potash,Céline S. Reinbold,Marcella Rietschel,Margarita Rivera,Mary Roberson,Martin Schalling,Peter R. Schofield,Thomas G. Schulze,Laura J. Scott,Alessandro Serretti,Engilbert Sigurdsson,Olav B. Smeland,Eystein Stordal,Fabian Streit,Jana Strohmaier,Thorgeir E. Thorgeirsson,Jens Treutlein,Gustavo Turecki,Arne E. Vaaler,Eduard Vieta,John B. Vincent,Yunpeng Wang,Stephanie H. Witt,Peter P. Zandi,Roger A.H. Adan,Lars Alfredsson,Tetsuya Ando,Harald N. Aschauer,Jessica H. Baker,Vladimir Bencko,Andrew W. Bergen,Andreas Birgegård,Vesna Boraska Perica,Harry Brandt,Roland Burghardt,Laura Carlberg,Matteo Cassina,Maurizio Clementi,Philippe Courtet,Steven Crawford,Scott J. Crow,James J. Crowley,Unna N. Danner,Oliver S. P. Davis,Daniela Degortes,Janiece E. DeSocio,Danielle M. Dick,Christian Dina,Elisa Docampo,Karin Egberts,Stefan Ehrlich,Thomas Espeseth,Fernando Fernández-Aranda,Manfred M. Fichter,Lenka Foretova,Monica Forzan,Giovanni Gambaro,Ina Giegling,Fragiskos Gonidakis,Philip Gorwood,Monica Gratacos Mayora,Yiran Guo,Katherine A. Halmi,Konstantinos Hatzikotoulas,Johannes Hebebrand,Sietske G. Helder,Beate Herpertz-Dahlmann,Wolfgang Herzog,Anke Hinney,Hartmut Imgart,Susana Jiménez-Murcia,Craig Johnson,Jennifer Jordan,Antonio Julià,Deborah Kaminská,Leila Karhunen,Andreas Karwautz,Martien J H Kas,Walter H. Kaye,Martin A. Kennedy,Youl-Ri Kim,Lars Klareskog,Kelly L. Klump,Gun Peggy Knudsen,Mikael Landén,Stephanie Le Hellard,Robert D. Levitan,Dong Li,Paul Lichtenstein,Mario Maj,Sara Marsal,Sara McDevitt,James R. Mitchell,Palmiero Monteleone,Alessio Maria Monteleone,Melissa A. Munn-Chernoff,Benedetta Nacmias,Marie Navratilova,Julie K. O'Toole,Leonid Padyukov,Jacques Pantel,Hana Papezova,Raquel Rabionet,Anu Raevuori,Nicolas Ramoz,Ted Reichborn-Kjennerud,Valdo Ricca,Marion Roberts,Dan Rujescu,Filip Rybakowski,André Scherag,Ulrike Schmidt,Jochen Seitz,Lenka Slachtova,Margarita C T Slof-Op 't Landt,Agnieszka Słopień,Sandro Sorbi,Lorraine Southam,Michael Strober,Alfonso Tortorella,Federica Tozzi,Janet Treasure,Konstantinos Tziouvas,Annemarie A. van Elburg,Tracey D. Wade,Gudrun Wagner,Esther Walton,Hunna J. Watson,H-Erich Wichmann,D. Blake Woodside,Eleftheria Zeggini,Stephanie Zerwas,Stephan Zipfel,Mark Adams,Till F. M. Andlauer,Klaus Berger,Elisabeth B. Binder,Dorret I. Boomsma,Enrique Castelao,Lucía Colodro-Conde,Nese Direk,Anna R. Docherty,Enrico Domenici,Katharina Domschke,Erin C. Dunn,Jerome C. Foo,E.J.C. de Geus,Hans J. Grabe,Steven P. Hamilton,Carsten Horn,Jouke-Jan Hottenga,David M. Howard,Marcus Ising,Stefan Kloiber,Douglas F. Levinson,Glyn Lewis,Patrik K. E. Magnusson,Hamdi Mbarek,Christel M. Middeldorp,Sara Mostafavi,Dale R. Nyholt,Brenda W.J.H. Penninx,Roseann E. Peterson,Giorgio Pistis,David J. Porteous,Martin Preisig,Jorge A. Quiroz,Catherine Schaefer,Eva C. Schulte,Jianxin Shi,Daniel J. Smith,Pippa A. Thomson,Henning Tiemeier,Rudolf Uher,Sandra Van der Auwera,Myrna M. Weissman,Madeline Alexander,Martin Begemann,Elvira Bramon,Nancy G. Buccola,Murray J. Cairns,Dominique Campion,Vaughan J. Carr,C. Robert Cloninger,David Cohen,David A. Collier,Aiden Corvin,Lynn E. DeLisi,Gary Donohoe,Frank Dudbridge,Jubao Duan,Robert B. Freedman,Pablo V. Gejman,Vera Golimbet,Stephanie Godard,Hannelore Ehrenreich,Annette M. Hartmann,Frans Henskens,Masashi Ikeda,Nakao Iwata,Assen Jablensky,Inge Joa,Erik G. Jönsson,Brian Kelly,Jo Knight,Bettina Konte,Claudine Laurent-Levinson,James Lee,Todd Lencz,Bernard Lerer,Carmel M. Loughland,Anil K. Malhotra,Jacques Mallet,Colm McDonald,Marina Mitjans,Bryan J. Mowry,Kieran C. Murphy,Robin M. Murray,F. Anthony O'Neill,Sang-Yun Oh,Aarno Palotie,Christos Pantelis,Ann E. Pulver,Tracey L. Petryshen,Digby Quested,Brien P. Riley,Alan R. Sanders,Ulrich Schall,Sibylle G. Schwab,Rodney J. Scott,Pak C. Sham,Jeremy M. Silverman,Kang Sim,Agnes A. Steixner,Paul A. Tooney,Jim van Os,Marquis P. Vawter,Dermot Walsh,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Brandon Wormley,Fuquan Zhang,Christos Androutsos,Paul D. Arnold,Cathy L. Barr,Csaba Barta,Katharina Bey,O. Joseph Bienvenu,Donald W. Black,Lawrence W. Brown,Cathy L. Budman,Danielle C. Cath,Keun-Ah Cheon,Valentina Ciullo,Barbara J. Coffey,Daniele Cusi,Lea K. Davis,Damiaan Denys,Christel Depienne,Andrea Dietrich,Valsamma Eapen,Peter Falkai,Thomas V. Fernandez,Blanca Garcia-Delgar,Daniel A. Geller,Donald L. Gilbert,Marco A. Grados,Erica Greenberg,Edna Grünblatt,Julie Hagstrøm,Gregory L. Hanna,Andreas Hartmann,Tammy Hedderly,Gary A. Heiman,Isobel Heyman,Hyun Ju Hong,Alden Y. Huang,Chaim Huyser,Laura Ibanez-Gomez,Ekaterina A. Khramtsova,Young Key Kim,Young Shin Kim,Robert A. King,Yun-Joo Koh,Anastasios Konstantinidis,Sodahm Kook,Samuel Kuperman,Bennett L. Leventhal,Christine Lochner,Andrea G. Ludolph,Marcos Madruga-Garrido,Irene A. Malaty,Athanasios Maras,James T. McCracken,Inge A. Meijer,Pablo Mir,Astrid Morer,Kirsten R. Müller-Vahl,Alexander Münchau,Tara Murphy,Allan L. Naarden,Peter Nagy,Gerald Nestadt,Paul S. Nestadt,Humberto Nicolini,Erika L. Nurmi,Michael S. Okun,Peristera Paschou,Fabrizio Piras,Federica Piras,Christopher Pittenger,Kerstin J. Plessen,Margaret A. Richter,Renata Rizzo,Mary M. Robertson,Veit Roessner,Stephan Ruhrmann,Jack Samuels,Paul Sandor,Monika Schlögelhofer,Eun-Young Shin,Harvey S. Singer,Dong-Ho Song,Jungeun Song,Gianfranco Spalletta,Dan J. Stein,S. Evelyn Stewart,Eric A. Storch,Barbara E. Stranger,Manfred Stuhrmann,Zsanett Tarnok,Jay A. Tischfield,Jennifer Tübing,Frank Visscher,Nienke Vulink,Michael Wagner,Susanne Walitza,Sina Wanderer,Martin Woods,Yulia Worbe,Gwyneth Zai,Samuel H. Zinner,Patrick F. Sullivan,Barbara Franke,Mark J. Daly,Cynthia M. Bulik,Andrew M. McIntosh,Michael Conlon O'Donovan,Amanda B Zheutlin,Ole A. Andreassen,Anders D. Børglum,Gerome Breen,Howard J. Edenberg,Ayman H. Fanous,Stephen V. Faraone,Joel Gelernter,Carol A. Mathews,Manuel Mattheisen,Karen S. Mitchell,Michael C. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Jeremiah M. Scharf,Murray B. Stein,Laura M. Thornton,James T.R. Walters,Naomi R. Wray,Naomi R. Wray,Daniel H. Geschwind,Benjamin M. Neale,Kenneth S. Kendler,Jordan W. Smoller +606 more
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.