R
Russell K. Durbin
Researcher at Rutgers University
Publications - 45
Citations - 3622
Russell K. Durbin is an academic researcher from Rutgers University. The author has contributed to research in topics: Virus & Sindbis virus. The author has an hindex of 30, co-authored 44 publications receiving 3465 citations. Previous affiliations of Russell K. Durbin include Ohio State University & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
David F. Stojdl,Brian D. Lichty,Benjamin R. tenOever,Jennifer M Paterson,Anthony T Power,Shane Knowles,Ricardo Marius,Jennifer Reynard,Laurent Poliquin,Harold L. Atkins,Earl G. Brown,Russell K. Durbin,Joan E. Durbin,John Hiscott,John C. Bell +14 more
TL;DR: Evidence is presented that the attenuated vesicular stomatitis strains, AV1 and AV2, embody all of the traits of an oncolytic virus, which will replicate preferentially in malignant cells, have the ability to treat disseminated metastases, and ultimately be cleared by the patient.
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The Role of Interferon in Influenza Virus Tissue Tropism
Adolfo García-Sastre,Russell K. Durbin,Hongyong Zheng,Peter Palese,Rachel Gertner,David E. Levy,Joan E. Durbin +6 more
TL;DR: The results demonstrate that type I interferon plays an important role in determining the pathogenicity and tissue restriction of influenza A/WSN/33 virus in vivo and in vitro.
Journal ArticleDOI
Recovery of Paramyxovirus Simian Virus 5 with a V Protein Lacking the Conserved Cysteine-rich Domain: The Multifunctional V Protein Blocks both Interferon-β Induction and Interferon Signaling
Biao He,Reay G. Paterson,Nicola Stock,Joan E. Durbin,Russell K. Durbin,Stephen Goodbourn,Richard E. Randall,Robert A. Lamb,Robert A. Lamb +8 more
TL;DR: SV5 blocks two distinct pathways of the innate immune response, both of which require the presence of the C-terminal specific cysteine-rich domain of the multifunctional SV5 V protein.
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The Role of IFN in Respiratory Syncytial Virus Pathogenesis
Joan E. Durbin,Joan E. Durbin,Teresa R. Johnson,Russell K. Durbin,Russell K. Durbin,Sara Mertz,Sara Mertz,Rafaella A. Morotti,Rafaella A. Morotti,R. Stokes Peebles,Barney S. Graham +10 more
TL;DR: It is demonstrated that wild-type memory CD4+ T cells stimulated by this peptide produce primarily IFN-γ, while STAT1−/−CD4+ cells produce primarily IL-13, which suggests that STAT1 activation by both type I (αβ) and type II (γ) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection.
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Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo
Nancy A. Jewell,Negin Vaghefi,Sara Mertz,Parvis Akter,R. Stokes Peebles,Lauren O. Bakaletz,Russell K. Durbin,Emilio Flaño,Joan E. Durbin +8 more
TL;DR: Investigation of type I IFN production triggered by RSV or influenza A virus infection of BALB/c mice found that while both viruses induced IFN-α/β production by pDCs in vitro, only influenza virus infection could stimulate type IIFN synthesis by p DCs in vivo.