Showing papers by "Rustam Aminov published in 2022"
TL;DR: The role of metabolomics in antimicrobial drug discovery and development is summarized and discussed, and the mechanisms of action of antimicrobials and non-antimicrobial compounds are revealed, and new ways to manage and control bacterial infections are opened.
Abstract: ABSTRACT Introduction In light of the ever-escalating problem of antimicrobial resistance, there is an urgent need for the development of new antimicrobials. In this review, the role of metabolomics in antimicrobial drug discovery and development is summarized and discussed. For this, ScienceDirect, PubMed, Web of Science and Google Scholar databases were searched with the article’s keywords and their combinations to retrieve the most relevant and up-to-date information. Areas covered The areas covered include the metabolomic concepts and techniques and bioinformatic tools used in metabolomics as well as recent developments in these areas. Also, examples of the use of metabolomics tools in several areas of antimicrobial drug discovery are given. Expert opinion Metabolomics, with the corresponding bioinformatic support and combination with other omics technologies, represents an integral and essential part of antimicrobial drug discovery and development. Metabolomics contributes to the mechanism-based approach in antimicrobial drug discovery, reveals the mechanisms of action of antimicrobials and non-antimicrobial compounds, identifies new targets, and opens new ways to manage and control bacterial infections.
4 citations
TL;DR: The results indicated the variability and dynamics in the epidemiology of salmonellosis and a high virulence potential of human NTS isolates circulating in the region.
Abstract: In this work, we analysed human isolates of nontyphoidal Salmonella enterica subsp. enterica (NTS), which were collected from salmonellosis cases in Armenia from 1996 to 2019. This disease became a leading food-borne bacterial infection in the region, with the younger age groups especially affected. The isolates were characterised by serotyping, Enterobacterial Repetitive Intergenic Consensus (ERIC-PCR) typing, and whole genome sequencing (WGS). The main serotypes were S. Typhimurium, S. Enteritidis, and S. Arizonae. ERIC-PCR indicated a high degree of clonality among S. Typhimurium strains, which were also multidrug-resistant and produced extended spectrum beta-lactamases. During the study period, the frequency of S. Typhimurium and S. Arizonae isolations decreased, but with the increase in S. Enteritidis and other NTS. A total of 42 NTS isolates were subjected to WGS and explored for virulence-related traits and the corresponding genetic elements. Some virulence and genetic factors were shared by all NTS serotypes, while the main differences were attributed to the serotype-specific diversity of virulence genes, SPIs, virulence plasmids, and phages. The results indicated the variability and dynamics in the epidemiology of salmonellosis and a high virulence potential of human NTS isolates circulating in the region.
4 citations
TL;DR: Aminov et al. as mentioned in this paper presented an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), provided the original author(s) and the copyright owners are credited and that the original publication in this journal is cited.
Abstract: COPYRIGHT © 2022 Aminov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Insights in antimicrobials, resistance, and chemotherapy: 2021
1 citations