R
Rustem I. Litvinov
Researcher at University of Pennsylvania
Publications - 164
Citations - 7127
Rustem I. Litvinov is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Fibrin & Platelet. The author has an hindex of 40, co-authored 150 publications receiving 5532 citations. Previous affiliations of Rustem I. Litvinov include Kazan Federal University.
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Book ChapterDOI
Fibrin Formation, Structure and Properties.
TL;DR: The X-ray crystallographic structure of major parts of fibrin(ogen), together with computational reconstructions of missing portions and numerous biochemical and biophysical studies, have provided a wealth of data to interpret molecular mechanisms offibrin formation, its organization, and properties.
Journal ArticleDOI
Mechanisms of fibrin polymerization and clinical implications
TL;DR: Research on all stages of fibrin polymerization, using a variety of approaches, has revealed aspects of the molecular mechanisms involved that are relevant for the pathogenesis of diseases, prophylaxis, diagnosis, and treatment.
Journal ArticleDOI
Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water
TL;DR: A molecular basis for the marked extensibility and negative compressibility of fibrin gels is proposed based on the structural and mechanical properties of clots at the network, fiber, and molecular levels.
Journal ArticleDOI
Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.
Douglas B. Cines,Tatiana Lebedeva,Chandrasekaran Nagaswami,Vincent Hayes,Walter Massefski,Rustem I. Litvinov,Lubica Rauova,Lubica Rauova,Thomas Jay Lowery,John W. Weisel +9 more
TL;DR: It is found that contracted clots develop a remarkable structure, with a meshwork of fibrin and platelet aggregates on the exterior of the clot and a close-packed, tessellated array of compressed polyhedrocytes within.
Journal ArticleDOI
Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations
Renhao Li,Neal Mitra,Holly Gratkowski,Gaston Vilaire,Rustem I. Litvinov,Chandrasekaran Nagasami,John W. Weisel,James D. Lear,William F. DeGrado,Joel S. Bennett +9 more
TL;DR: The results suggest that homomeric associations involving transmembrane domains provide a driving force for integrinactivation and suggest a structural basis for the coincidence of integrin activation and clustering.