Rutger J. Hassink

TL;DR: A striking inverse relationship between cardiomyocyte differentiation and the concentration of FCS is demonstrated during HES‐2‐END‐2 coculture, and this model represents an improved in vitro model, without interfering factors in serum, for testing other factors that might promote cardiomeocyte differentiation.

TL;DR: Characterization of the redifferentiation capabilities of cultured adult cardiac myocytes in culture provides an important system for comparing cardiomyocytes differentiating from human stem cells and provides the basis for an in vitro transplantation model to study interaction and communication between primary adult and stem cell-derived cardiomeocytes.

TL;DR: This study shows that paroxysmal atrial fibrillation causes significant impairment of quality of life, and symptomatology and autonomic function are important predictors ofquality of life in this patient group.

TL;DR: It seems appropriate to only screen for PVS in patients with suggestive symptoms after RFCA of atrial fibrillation, as incidence of severe PVS was <1% and incidence of symptomatic PVS necessitating intervention was negligible.

TL;DR: Five-year freedom of atrial tachyarrhythmia could be achieved by PVAI as primary ablation strategy in 58.3% of patients, and independent predictors for arrhythmic recurrence were non-paroxysmal AF, female sex, body mass index, hypertension, and AF duration.