Ryosuke Murata

TL;DR: It was concluded that the working crude toxins may be used for the antitoxin titration in the present micro cell culture method and the MCD values obtained were almost identical to the minimal reactive dose (MRD) as determined by the rabbit skin test.

TL;DR: It is concluded that the micro cell culture colour change method using VERO cells is a highly recommended procedure for diphtheria toxin and antitoxin determinations because of its sensitivity, reproducibility and economy of time, labour and materials.

TL;DR: The purified serum factor inhibited the two immunologically distinct hemorhagic principles in the venom of this snake and antihemorrhagic activities against HR1 and HR2 increased simultaneously during purification, resulting in a 21-fold increase in specific activity.