Ryuji Inoue

TL;DR: It is found that heterologous expression of murine TRP6 in HEK293 cells reproduces almost exactly the essential biophysical and pharmacological properties of &agr;1-adrenoceptor–activated nonselective cation channels (&agr–1-AR–NSCC) previously identified in rabbit portal vein smooth muscle.

TL;DR: Findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families.

TL;DR: These findings reveal an interesting correspondence of TRP7 to the background and receptor stimulation-induced cation currents in various native systems and suggest that the TRP6 channel is a new member of diacylglycerol-activated cation channels.

TL;DR: Data suggest that DAG‐induced Ca2+ signaling pathway through TRPC3 and TRPC6 is essential for Ang II‐induced NFAT activation and cardiac hypertrophy.

TL;DR: An overview of the current knowledge on TRP proteins is provided and new lines of evidence suggest that TRPV2 may act as a Ca2+-overloading pathway associated with dystrophic cardiomyopathy,TRPV4 as a mediator of endothelium-dependent hyperpolarization, TRPM7 as a proproliferative vascular Mg2+ entry channel, and TRPP2 as aCa2-entry channel requisite for vascular integrity.