Takashi Yoshida

TL;DR: It is reported that a widely expressed Ca2+-permeable cation channel, LTRPC2, activated by micromolar levels of H2O2 and agents that produce reactive oxygen/nitrogen species represents an important intrinsic mechanism that mediatesCa2+ and Na+ overload in response to disturbance of redox state in cell death.

TL;DR: Findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families.

TL;DR: TheTRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TR PC3-related diseases such as cardiac hypertrophy.

TL;DR: This work investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells, and found that preferred orientations of clonALLY related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex.

TL;DR: In this article, the nonlinear Brownian rotational relaxation of magnetic fluids for the case of large excitation field was studied in relation to its biomedical applications and the Fokker-Planck equation was solved by numerical simulation when a large step or a sinusoidal field was applied.