S. De Cosmo

TL;DR: Early morning increases in plasma glucose concentrations and insulin requirements observed in IDDM and NIDDM may be an exaggeration of a physiologic circadian variation in hepatic insulin sensitivity induced by antecedent changes in catecholamine and/or growth hormone secretion.

TL;DR: Several lines of evidence suggest a pathogenic role of insulin resistance on kidney dysfunction, and numerous independent intervention studies have shown that a favourable modulation of insulin Resistance has a positive effect also on urinary albumin and total protein excretion.

TL;DR: It is concluded that this test, when performed in standardized conditions, is safe and reproducible and can reliably predict those patients with type I diabetes who are at risk of developing severe hypoglycemia during intensive insulin therapy.

TL;DR: It is concluded that glucose counterregulatory mechanisms differ during short-term and prolonged hypoglycemia, with only an increase in glucose production mediated by suppression of insulin secretion and increased glucagon secretion involved during the former, whereas during prolongedhypoglyceia, both a suppression of glucose utilization, and an increaseIn glucose production are important.

TL;DR: This is the first study which provides insights into the applicability and accuracy of ECG stress in screening SMI in high-risk patients with T2D, due to the high prevalence of CAD.