S
S. Kobayashi
Researcher at University of Virginia
Publications - 4
Citations - 656
S. Kobayashi is an academic researcher from University of Virginia. The author has contributed to research in topics: Myosin phosphatase activity & Phosphorylation. The author has an hindex of 4, co-authored 4 publications receiving 651 citations.
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Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in pharmacomechanical coupling.
TL;DR: It is shown that in smooth muscle permeabilized with beta-escin, one of the saponin esters, alpha 1-adrenergic and muscarinic agonists, as well as caffeine and InsP3, cause contractions mediated by Ca2+ release, which supports the conclusion that InsP 3 is the major physiological messenger of the Ca 2+ release component of pharmacomechanical coupling.
Journal ArticleDOI
Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium
Ming C. Gong,A. Fuglsang,Dario R. Alessi,S. Kobayashi,P. Cohen,Avril V. Somlyo,Andrew P. Somlyo +6 more
TL;DR: It is concluded that AA may act as a messenger-promoting protein phosphorylation through direct inhibition of the form of protein phosphatase(s) that dephosphorylate MLC20 in vivo.
Journal ArticleDOI
Ca2+ channel blockers distinguish between G protein-coupled pharmacomechanical Ca2+ release and Ca2+ sensitization
TL;DR: The findings raise the possibility that pharmacomechanical Ca2+ release may be modulated by dihydropyridine binding proteins at the level of G proteins/phospholipase C and also indicate a divergence of the Ca2(+)-releasing and Ca2-sensitizing effects at some step prior to phospholipases C.