A new protein has been isolated from E. coli which causes specific termination and release of RNA during synthesis in vitro. It has been given the name ρ-factor.

Termination Factor for RNA Synthesis

ρ factor-mediated transcription termination at the tR1 terminator site of bacteriophage λ is examined. Mutations affecting the termination event are characterised. These mutations define features of the site which seem to be important to terminator function. In addition, other related transcriptional and translational regulatory elements are defined within the region surrounding the termination site. The potential molecular interactions and structural overlaps of these control signals apparently couple the regulation of the decision between lytic and lysogenic growth patterns by phage λ.

The relationship between function and DNA sequence in an intercistronic regulatory region in phage λ

Nonproductive infection of baby hamster kidney cells (BHK21) with adenovirus type 12.

https://shapiro.bsd.uchicago.edu/Shapiro1969.JMB.pdf

S. Packman

Papers

Constitutive λ DNA replication by λc17, a regulatory mutant related to virulence