S
S Saarinen
Researcher at Karolinska Institutet
Publications - 5
Citations - 395
S Saarinen is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Primary sclerosing cholangitis & Haplotype. The author has an hindex of 4, co-authored 5 publications receiving 383 citations.
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Journal ArticleDOI
Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis
TL;DR: Autoimmune disorders are more frequent among PSC patients compared to IBD patients without liver disease, and Associated autoimmune diseases in P SC patients does not influence the outcome or clinical presentation of PSC.
Journal ArticleDOI
HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations
Anne Spurkland,S Saarinen,Kirsten Muri Boberg,S A Mitchell,Ulrika Broomé,Llorenç Caballería,E. Ciusani,Roger W. Chapman,Guadalupe Ercilla,O Fausa,Ingebjørg Knutsen,Albert Parés,Floriano Rosina,Olle Olerup,Erik Thorsby,Erik Schrumpf +15 more
TL;DR: The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations and PSC was found to be positively associated to three different HLAclass II haplotypes.
Journal ArticleDOI
The HLA-DR3,DQ2 Heterozygous Genotype is Associated with an Accelerated Progression of Primary Sclerosing Cholangitis
Kirsten Muri Boberg,Anne Spurkland,Giuseppe Rocca,T Egeland,S Saarinen,S A Mitchell,Ulrika Broomé,Roger W. Chapman,Olle Olerup,Albert Parés,Floriano Rosina,Erik Schrumpf +11 more
TL;DR: This study investigated whether HLA class II genes associated with PSC are also related to disease progression, and found that the presence of a DQ6 encoding haplotype in DR3,DQ2 negative individuals was associated with a reduced risk of death or liver transplantation.