S
S T Lee
Researcher at Agency for Science, Technology and Research
Publications - 22
Citations - 1235
S T Lee is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cancer & Methyltestosterone. The author has an hindex of 14, co-authored 22 publications receiving 1087 citations. Previous affiliations of S T Lee include Singapore General Hospital & Genome Institute of Singapore.
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Journal ArticleDOI
Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.
S T Lee,Zhimei Li,Zhenlong Wu,Meiyee Aau,Peiyong Guan,R.K. Murthy Karuturi,Yih-Cherng Liou,Qiang Yu,Qiang Yu +8 more
TL;DR: This work uncovers an unexpected role of EZH2 in conferring the constitutive activation of NF-κB target gene expression in ER-negative basal-like breast cancer cells and functions as a double-facet molecule in breast cancers.
Journal ArticleDOI
FOXQ1 Regulates Epithelial-Mesenchymal Transition in Human Cancers
TL;DR: RNAi-mediated suppression of FOXQ1 expression in highly invasive human breast cancer cells reversed EMT, reduced invasive ability, and alleviated other aggressive cancer phenotypes manifested in 3-dimensional Matrigel (BD Biosciences) culture.
Journal ArticleDOI
PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Jing Tan,Zhimei Li,Puay Leng Lee,Peiyong Guan,Mei Yee Aau,S T Lee,Min Feng,Cheryl Zi Hui Lim,Eric Yong Jing Lee,Zhen Ning Wee,Yaw Chyn Lim,R.K. Murthy Karuturi,Qiang Yu +12 more
TL;DR: The findings identify a novel pathway in human cancer and CSC activation and provide a therapeutic strategy for targeting MYC-associated tumorigenesis and therapeutic resistance, and targeted inhibition of PDK1/PLK1 is robust in targeting MyC dependency in cancer cells.
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Blood Concentrations of Lead, Cadmium, Mercury, Zinc, and Copper and Human Semen Parameters
TL;DR: Significant correlations were observed between blood cadmium levels and volume of semen, midpiece defects, and immature forms of spermatozoa, which may have an effect on spermatogenesis.
Journal ArticleDOI
Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage.
Z Wu,S T Lee,Yuanyuan Qiao,Yuanyuan Qiao,Z M Li,P L Lee,Youngjoo Lee,X Jiang,Jing Tan,Meiyee Aau,C Z H Lim,Qiang Yu,Qiang Yu +12 more
TL;DR: It is shown that EZH2 is an important determinant of cell fate decision in response to genotoxic stress and a crucial role of EZh2 in determining the cancer cell outcome following DNA damage is unraveled, suggesting that therapeutic targeting oncogenic EH2 might serve as a strategy for improving conventional chemotherapy in a given malignancy.