J
Jing Tan
Researcher at Sun Yat-sen University
Publications - 65
Citations - 4258
Jing Tan is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 23, co-authored 53 publications receiving 3362 citations. Previous affiliations of Jing Tan include Guangzhou Medical University & Agency for Science, Technology and Research.
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Journal ArticleDOI
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
Jing Tan,Xiaojing Yang,Li Zhuang,Xia Jiang,Wei Chen,Puay Leng Lee,R.K. Murthy Karuturi,Patrick Tan,Edison T. Liu,Qiang Yu +9 more
TL;DR: The results demonstrate the unique feature of DZNep as a novel chromatin remodeling compound and suggest that pharmacologic reversal of PRC2-mediated gene repression by DzNep may constitute a novel approach for cancer therapy.
Journal ArticleDOI
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Apinya Jusakul,Apinya Jusakul,Ioana Cutcutache,Chern Han Yong,Jing Quan Lim,Mi Ni Huang,Nisha Padmanabhan,Vishwa Nellore,Sarinya Kongpetch,Alvin Wei Tian Ng,Ley Moy Ng,Su Pin Choo,Swe Swe Myint,Raynoo Thanan,Sanjanaa Nagarajan,Weng Khong Lim,Cedric Chuan Young Ng,Arnoud Boot,Mo Liu,Choon Kiat Ong,Vikneswari Rajasegaran,Stefanus Lie,Alvin Soon Tiong Lim,Tse Hui Lim,Jing Tan,Jia Liang Loh,John R. McPherson,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Puangrat Yongvanit,Sopit Wongkham,Yasushi Totoki,Hiromi Nakamura,Yasuhito Arai,Satoshi Yamasaki,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P.J. Ooi,Kiat Hon Lim,Simona Dima,Dan G. Duda,Irinel Popescu,Philippe Broët,Sen-Yung Hsieh,Ming-Chin Yu,Aldo Scarpa,Jiaming Lai,Di-Xian Luo,André Lopes Carvalho,André Luiz Vettore,Hyungjin Rhee,Young Nyun Park,Ludmil B. Alexandrov,Raluca Gordân,Steven G. Rozen,Tatsuhiro Shibata,Chawalit Pairojkul,Bin Tean Teh,Patrick Tan +58 more
TL;DR: In this paper, the authors analyzed 489 cholangiocarcinoma (CCA) from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information.
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Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
TL;DR: It is reported that cancer cells with elevated E2F1 activity are highly susceptible to HDACI-induced cell death and predicted that, clinically, HDACIs will be more effective in tumors with high E1A oncogene activity.
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DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
Xia Jiang,Jing Tan,Jingsong Li,Saul Kivimäe,Xiaojing Yang,Li Zhuang,Puay Leng Lee,Mark T.W. Chan,Lawrence W. Stanton,Edison T. Liu,Benjamin N.R. Cheyette,Qiang Yu +11 more
TL;DR: DACT3 expression can be robustly derepressed by a pharmacological combination that simultaneously targets both histone methylation and deacetylation, leading to strong inhibition of Dishevelled (Dvl)-mediated Wnt/beta-catenin signaling and massive apoptosis of colorectal cancer cells.
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Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Tammy Song,Maarja-Liisa Nairismagi,Yurike Laurensia,Jing Quan Lim,Jing Tan,Zhi Mei Li,Wan Lu Pang,Atish Kizhakeyil,Giovani Claresta Wijaya,Dachuan Huang,Sanjanaa Nagarajan,Burton Kuan Hui Chia,Daryl Ming Zhe Cheah,Yan Hui Liu,Fen Zhang,Hui Lan Rao,Tiffany Tang,Esther Kam Yin Wong,Jin Xin Bei,Jabed Iqbal,Jabed Iqbal,Nicholas Francis Grigoropoulos,Siok Bian Ng,Wee Joo Chng,Bin Tean Teh,Soo Yong Tan,Navin Kumar Verma,Hao Fan,Hao Fan,Soon Thye Lim,Choon Kiat Ong +30 more
TL;DR: It is demonstrated that STAT3 activation confers high PD-L1 expression, which may promote tumor immune evasion and the combination of PD-1/PD-L 1 antibodies and STAT3 inhibitors might be a promising therapeutic approach for NKTL, and possibly PTCL.