S
S Takaki
Researcher at Kumamoto University
Publications - 12
Citations - 1102
S Takaki is an academic researcher from Kumamoto University. The author has contributed to research in topics: Interleukin-5 receptor & Complementary DNA. The author has an hindex of 9, co-authored 12 publications receiving 1096 citations.
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Journal ArticleDOI
Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.
Akira Tominaga,S Takaki,N Koyama,Shigeki Katoh,R Matsumoto,Masahiro Migita,Yasumichi Hitoshi,Y Hosoya,S Yamauchi,Y Kanai +9 more
TL;DR: It is suggested that aberrant expression of the IL-5 gene may induce accumulation of Ly-1+ B cells and eosinophils in vivo, and the role ofIL-5 in the differentiation ofLy-1+, which has been considered to produce autoantibodies, is determined by using this mouse.
Journal ArticleDOI
Molecular cloning and expression of the murine interleukin-5 receptor.
S Takaki,Akira Tominaga,Yasumichi Hitoshi,Seiji Mita,Eiichiro Sonoda,Naoto Yamaguchi,Kiyoshi Takatsu +6 more
TL;DR: Homology search for the amino acid sequence of the IL‐5 receptor reveals that the IL-5 receptor contains a common motif of a cytokine receptor family that is recently identified.
Journal ArticleDOI
Molecular cloning and expression of the human interleukin 5 receptor.
TL;DR: The human IL-5 receptor characterized in this paper is essential for signal transduction, because expression of this molecule in murine IL-3-dependent cell line FDC-P1 allowed these cells to proliferate in response to IL- 5.
Journal ArticleDOI
Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.
S Takaki,Seiji Mita,Toshio Kitamura,S. Yonehara,Naoto Yamaguchi,Akira Tominaga,A. Miyajima,Kiyoshi Takatsu +7 more
TL;DR: The high affinity IL‐5‐R was reconstituted on an L cell transfectant co‐expressing AIC2B and p60 IL‐ 5‐R, whereas only the low affinity IL-5‐ R was detected on a transfectants co‐ expressing Aic2A and p 60 IL‐4‐R.
Journal Article
Distribution of IL-5 receptor-positive B cells. Expression of IL-5 receptor on Ly-1(CD5)+ B cells.
Yasumichi Hitoshi,Naoto Yamaguchi,Seiji Mita,Eiichiro Sonoda,S Takaki,Akira Tominaga,Kiyoshi Takatsu +6 more
TL;DR: The results suggest that IL-5R+ B cells may consist of a subpopulation of B cells, and a significant proportion of splenic B cells reacted with these mAb, although lower number (one-log less) than peritoneal B cells and a small proportion of H7dull+ splenicB cells seems to be Ly-1(CD5)dull+,