S. Zimmer

TL;DR: It is believed that only a combination of drugs can effectively control the posttraumatic dyshomeostasis of the various cell systems and that immune modulatory interventions should be started as early as possible after trauma in a preventive fashion to protect against organ tissue destruction.

TL;DR: A high risk patient subpopulation that is characterized by high proinflammatory cytokine synthesis and suppressed antigen presentation and that contributes to a disruption of adequate MΦ/T-cell interaction, rendering the host anergic toward opportunistic infections is found.

TL;DR: The study was performed to further elucidate the mechanisms of dysfunctional T- cell activation following extensive burn and mechanical injuries and to scrutinize if inadequate lymphokine production after trauma is possibly a result of defective transduction of extracellular signals to the T-cell nucleus.

TL;DR: Cytokine patterns found in this study suggest that after low-dose endotoxin administration the T-cell immune response is shifted towards the Th2 cell type response, which may contribute to the depressed cell-mediated immune response associated with sepsis.

TL;DR: There was no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome, but persistently high concentrations of IL-8, ENA-78, and sP-selectin were found during recovery from the injuries, but sE- selectin was increased only during the first week after major trauma.