R
Roberto P. Garofalo
Researcher at University of Texas Medical Branch
Publications - 179
Citations - 12005
Roberto P. Garofalo is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Chemokine & Innate immune system. The author has an hindex of 66, co-authored 169 publications receiving 11007 citations. Previous affiliations of Roberto P. Garofalo include University at Buffalo & National Institutes of Health.
Papers
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Journal ArticleDOI
Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses
Timothy P. Welliver,Roberto P. Garofalo,Yashoda M. Hosakote,Karen H. Hintz,Luis F. Avendaño,Katherine Sánchez,Luis Velozo,Hasan S. Jafri,Susana Chavez-Bueno,Pearay L. Ogra,Lu Ann McKinney,Jennifer L. Reed,Robert C. Welliver +12 more
TL;DR: Severe infantile RSV and influenza virus LRTI is characterized by inadequate (rather than excessive) adaptive immune responses, robust viral replication, and apoptotic crisis.
Journal ArticleDOI
Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells
TL;DR: Findings indicate distinct temporal roles of RIG-I and TLR3 in mediating RSV-induced innate immune responses, which are coupled to distinct pathways controlling NF-κB activation.
Journal ArticleDOI
Metapneumovirus and acute wheezing in children
Tuomas Jartti,Bernadette G. van den Hoogen,Roberto P. Garofalo,Albert D. M. E. Osterhaus,Olli Ruuskanen +4 more
TL;DR: Human metapneumovirus is a clinically important causative agent of acute wheezing in young children and regulated upon activation.
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Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection.
Roberto P. Garofalo,Jan L.L. Kimpen,Jan L.L. Kimpen,Robert C. Welliver,Robert C. Welliver,Pearay L. Ogra +5 more
TL;DR: The data suggest that eosinophil degranulation in the respiratory tract occurs during RSV bronchiolitis and may play a significant role in the development of virus-induced airway obstruction.
Journal ArticleDOI
Cell-Specific Expression of RANTES, MCP-1, and MIP-1α by Lower Airway Epithelial Cells and Eosinophils Infected with Respiratory Syncytial Virus
Barbara Olszewska-Pazdrak,Antonella Casola,Tadahito Saito,Rafeul Alam,Sheila E. Crowe,Fang C Mei,Pearay L. Ogra,Roberto P. Garofalo +7 more
TL;DR: The inflammatory process in RSV-induced bronchiolitis appears to be triggered by the infection of epithelial cells and further amplified via mechanisms driven by IFN-γ and by the secretion of eosinophil chemokines.