S
Saba Abdul-Hussein
Researcher at Laboratory of Molecular Biology
Publications - 2
Citations - 121
Saba Abdul-Hussein is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Integral membrane protein & G protein-coupled receptor. The author has an hindex of 2, co-authored 2 publications receiving 98 citations.
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Journal ArticleDOI
A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies
Francesca Magnani,Maria Josefa Serrano-Vega,Yoko Shibata,Saba Abdul-Hussein,Guillaume Lebon,Jennifer L. Miller-Gallacher,Ankita Singhal,Annette Strege,Jennifer Thomas,Christopher G. Tate +9 more
TL;DR: A thermostabilization strategy based on systematic mutagenesis coupled to a radioligand-binding thermostability assay that can be applied to receptors, ion channels and transporters and facilitated structure-based drug design applied to GPCRs.
Journal ArticleDOI
Thermostabilisation of the serotonin transporter in a cocaine-bound conformation.
TL;DR: Conformational thermostabilisation is equally applicable to membrane proteins that are transporters in addition to those that are GPCRs, making them promising candidates for crystallisation.