S
Sachiko Furuichi
Researcher at University of Tokushima
Publications - 17
Citations - 501
Sachiko Furuichi is an academic researcher from University of Tokushima. The author has contributed to research in topics: Cytokine & Interleukin. The author has an hindex of 11, co-authored 17 publications receiving 490 citations.
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Journal ArticleDOI
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation
Masato Okamoto,Sachiko Furuichi,Yasuhiko Nishioka,Tetsuya Oshikawa,Tomoyuki Tano,Sharif Uddin Ahmed,Kiyoshi Takeda,Shizuo Akira,Yoshiki Ryoma,Yoichiro Moriya,Motoo Saito,Saburo Sone,Mitsunobu Sato +12 more
TL;DR: It is suggested that OK-PSA may be a potent adjuvant for local DC therapy, and that DC therapy followed by OK- PSA is able to elicit anticancer activity even in aTLR4-deficient host when TLR4 is expressed only in DCs injected intratumorally.
Journal ArticleDOI
Involvement of Toll-Like Receptor 4 Signaling in Interferon-γ Production and Antitumor Effect by Streptococcal Agent OK-432
Masato Okamoto,Tetsuya Oshikawa,Tomoyuki Tano,Go Ohe,Sachiko Furuichi,Hidetomo Nishikawa,Sharif Uddin Ahmed,Sachiko Akashi,Kensuke Miyake,Osamu Takeuchi,Shizuo Akira,Yoichiro Moriya,Shuzo Matsubara,Yoshiki Ryoma,Motoo Saito,Mitsunobu Sato +15 more
TL;DR: TLR4 and MD-2 may mediate OK-432-induced anticancer immunity and be associated with the in vivo IFN-gamma induction in 19 patients administeredOK-432.
Journal ArticleDOI
Mechanism for bone invasion of oral cancer cells mediated by interleukin‐6 in vitro and in vivo
Masato Okamoto,Kenji Hiura,Go Ohe,Yasuo Ohba,Kunihoro Terai,Tetsuya Oshikawa,Sachiko Furuichi,Hidetomo Nishikawa,Keiji Moriyama,Hideo Yoshida,Mitsunobu Sato +10 more
TL;DR: Although interleukin (IL)‐6 accelerates osteoclastic bone resorption, it remains unclear whether IL‐6 may be involved in bone invasion of oral cancer.
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Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice.
Masato Okamoto,Tetsuya Oshikawa,Go Ohe,Hidetomo Nishikawa,Sachiko Furuichi,Tomoyuki Tano,Yoichiro Moriya,Motoo Saito,Mitsunobu Sato +8 more
TL;DR: It is suggested that TLR4 signaling is involved in regulating OK-PSA-induced anti-cancer immunity and is implicated in lipopolysaccharide-induced cell signaling.
Journal ArticleDOI
Induction of Th1-type cytokines by lipoteichoic acid-related preparation isolated from OK-432, a penicillin-killed streptococcal agent.
Masato Okamoto,Go Ohe,Tetsuya Oshikawa,Hidetomo Nishikawa,Sachiko Furuichi,Hideo Yoshida,Takashi Matsuno,Motoo Saito,Mitsunobu Sato +8 more
TL;DR: Findings clearly indicated that OK-PSA, an LTA-related molecule, is a main effective component of OK-432, and is a potent inducer of Th1-type cytokines by T cell and natural killer (NK) cell activation mediated by monocytes-derived IL-18, and that it may be a useful immunotherapeutic agent for the patients with malignancies better than original Ok-432.