S
Sadia A. Hessein
Researcher at Al-Azhar University
Publications - 8
Citations - 126
Sadia A. Hessein is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Moiety & Chemistry. The author has an hindex of 4, co-authored 6 publications receiving 57 citations.
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Journal ArticleDOI
Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies
Yousry A. Ammar,Awatef A. Farag,Abeer M. Ali,Sadia A. Hessein,Ahmed A. Askar,Eman A. Fayed,Doaa M. Elsisi,Ahmed Ragab +7 more
TL;DR: The most potent compounds 2, 7, 9, 10, 12 and 13c were exhibited bactericidal activity, in addition to fungistatic activity by dead live assay, and showed a significant result against all multi-drug resistance (MDRB) used especially compound 13c that displayed the best results with MICs of MDRB.
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One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study
Yousry A. Ammar,Sondos M.A. Abd El-Hafez,Sadia A. Hessein,Abeer M. Ali,Ahmed A. Askar,Ahmed Ragab +5 more
TL;DR: Molecular docking study against DHFR enzyme (1DLS) was carried out, and the active derivatives bind to some the nearly the same amino acid residues as MTX that support the hypothesis that quinoline antibiotic class can be solved by discovering new targets and inhibitors.
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Synthesis and Antimicrobial Activity of Furochromone, Benzofuran and Furocoumarin Derivatives Bearing Sulfonyl Moiety
TL;DR: Benzofuran derivatives 11−14 (visnaginone derivatives), which showed the lowest antimicrobial activity among all the compounds investigated in this study, are moderately active against all the tested strains.
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Synthesis of Chromen-2-one, Pyrano[3,4-c]chromene and Pyridino[3,4-c]chromene Derivatives as Potent Antimicrobial Agents
TL;DR: The majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi.
Journal ArticleDOI
Development and radiosterilization of new hydrazono‐quinoline hybrids as DNA gyrase and topoisomerase IV inhibitors: Antimicrobial and hemolytic activities against uropathogenic isolates with molecular docking study
Yousry A. Ammar,Jehan A. Micky,Dina S Aboul-Magd,Sondos M A Abd El-Hafez,Sadia A. Hessein,Abeer M. Ali,Ahmed Ragab +6 more
TL;DR: The study suggests that the hydrazono-quinoline analogs exert their antibacterial activity as dual inhibitors for DNA gyrase and DNA topoisomerase IV enzymes with IC50 values ranging between (4.67 ± 0.45) and (6.4 - 20.4) μM, respectively.