Awatef A. Farag

TL;DR: New series of Schiff’s bases, hydrazones, thiosemicarbazone derivatives, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of primary amines,Hydrazine hydrate, andThiocarbohydrazides and exhibited antiviral activity.

TL;DR: Many derivatives of heterocyclic compounds containing a sulfonamide thiazole moiety were synthesized through the reaction of 2‐(cyano or chloro)‐N‐(4‐(N‐thiazol‐2‐ylsulfamoyl)phenyl)acetamide with isocyanate and 6 compounds showed protection against picrotoxin‐induced convulsion.

TL;DR: The most potent compounds 2, 7, 9, 10, 12 and 13c were exhibited bactericidal activity, in addition to fungistatic activity by dead live assay, and showed a significant result against all multi-drug resistance (MDRB) used especially compound 13c that displayed the best results with MICs of MDRB.

TL;DR: Some of new 3-(4-chlorophenyl or 4-fluorophenyl)-6-iodo-4-oxo-3,4-dihydroquinazoline derivatives having a Schiff bases, oxazolone, imidazolidine, pyrazolidines, pyridine, pyrimidine, and various substituted C-2 have been synthesized.

TL;DR: Molecular docking studies of the promising derivatives into DNA Gyrase binding site proved the usefulness of hybridizing quinoxaline scaffold with SO2 and morpholine moieties as a hopeful strategy in designing new DNA Gyrsase binding molecules.