Samir Y. Abbas

TL;DR: Novel 3-aryl-4(3H)-quinazolinone-2-carboxaldehydes, their corresponding Schiff's base and thiosemicarbazone derivatives were synthesized from the starting 5-iodo anthranilic acid and screened for some selected compounds to probe their potential anticonvulsant, analgesic, cytotoxic as well as their antimicrobial activities.

TL;DR: The synthesized quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antibacterial and antifungal agents according to the tested strains of bacteria and fungi.

TL;DR: New series of 5-(morpholinosulfonyl) isatin derivatives were designed and synthesized and showed inhibitory activity against EGFR with IC50 values less than 2 μM, while the most potent EGFR inhibitors 7b and 10 showed to cause cell cycle arrest at G2/M phase and induce apoptosis.

TL;DR: New series of thiourea derivatives incorporating a hippuric acid moiety comprising a new class of promising broad-spectrum antibacterial and antifungal agents are synthesized through the reaction of 4-hippuric acids with nitrogen nucleophiles.

TL;DR: New series of Schiff’s bases, hydrazones, thiosemicarbazone derivatives, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of primary amines,Hydrazine hydrate, andThiocarbohydrazides and exhibited antiviral activity.