Sae Rin Jean

TL;DR: In this article, a number of small molecule, peptide-base, liposome, and nanoparticle-based transport vectors have been proposed to facilitate transport of a variety of compounds for mitochondrial delivery.

TL;DR: The features of existing delivery vectors developed for targeting probes and therapeutics to this highly impermeable organelle are summarized and the major applications of mitochondrial targeting of bioactive molecules are discussed, which include the detection and treatment of oxidative damage, combating bacterial infections, and the development of new therapeutic approaches for cancer.

TL;DR: Self-assembled quantum dot DNA hydrogels that exhibit both size and spectral tunability and can be used for delivery of doxorubicin, an anticancer drug, to increase potency 9-fold against cancer cells are reported.

TL;DR: A chemically modified mitochondria-targeted Dox (mtDox) is proposed as a new effective agent with a safer toxicity profile compared with Dox that may be effective for the treatment of Dox-resistant/Pgp-positive osteosarcoma patients, who strongly need alternative and innovative treatment strategies.

TL;DR: Recent significant advances in mitochondrial chemical biology are highlighted, focusing on the development of chemical tools to perturb mitochondrial biochemistry, probes allowing precise measurement of mitochondrial function, and new techniques for high-throughput characterization of the mitochondrial proteome.