V
Valentina Audrito
Researcher at University of Turin
Publications - 49
Citations - 1696
Valentina Audrito is an academic researcher from University of Turin. The author has contributed to research in topics: Nicotinamide phosphoribosyltransferase & NAD+ kinase. The author has an hindex of 20, co-authored 42 publications receiving 1207 citations.
Papers
More filters
Journal ArticleDOI
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network.
Valentina Audrito,Tiziana Vaisitti,Davide Rossi,Daniela Gottardi,Giovanni D'Arena,Luca Laurenti,Gianluca Gaidano,Fabio Malavasi,Silvia Deaglio +8 more
TL;DR: It is concluded that nicotinamide has the dual property of inhibiting SIRT1 through a noncompetitive enzymatic block ( p53 independent) and at the same time through miR-34a induction (p53 dependent).
Journal ArticleDOI
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.
Valentina Audrito,Sara Serra,Davide Brusa,Francesca Mazzola,Francesca Arruga,Tiziana Vaisitti,Marta Coscia,Rossana Maffei,Davide Rossi,Tao Wang,Giorgio Inghirami,Giorgio Inghirami,Giorgio Inghirami,Menico Rizzi,Gianluca Gaidano,Joe G.N. Garcia,Cynthia Wolberger,Nadia Raffaelli,Silvia Deaglio +18 more
TL;DR: It is shown that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic leukemia (CLL) patients, revealing that eNAMPT is a critical element in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.
Journal ArticleDOI
PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics
Daniela Massi,Davide Brusa,Barbara Merelli,Michela Ciano,Valentina Audrito,Sara Serra,Roberta Buonincontri,Gianna Baroni,Romina Nassini,Daiana Minocci,Laura Cattaneo,Elena Tamborini,Alessandra Carobbio,Eliana Rulli,Silvia Deaglio,Mario Mandalà +15 more
TL;DR: Clinical and experimental data suggest that PD-L1(+) melanomas should be considered a disease subset with distinct genetic and morpho-phenotypic features, leading to enhanced aggressiveness and invasiveness.
Journal ArticleDOI
The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600
D. Massi,Davide Brusa,Barbara Merelli,C. Falcone,Gongda Xue,A. Carobbio,Romina Nassini,Gianna Baroni,Elena Tamborini,Laura Cattaneo,Valentina Audrito,Silvia Deaglio,Mario Mandalà +12 more
TL;DR: The results provide the first proof-of-principle evidence for the predictive and prognostic relevance of PD-L1 immunohistochemical expression and density of immune cell infiltration in BRAF(V600)-mutated MMP treated with BRAFi.
Journal ArticleDOI
NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation.
TL;DR: Elevated eNAMPT were reported in several metabolic and inflammatory disorders, including obesity, diabetes, and cancer, while eNAPRT is emerging as a biomarker of sepsis and septic shock.