S
Sae Rin Jean
Researcher at University of Toronto
Publications - 11
Citations - 757
Sae Rin Jean is an academic researcher from University of Toronto. The author has contributed to research in topics: DNA repair & Mitochondrial DNA. The author has an hindex of 9, co-authored 11 publications receiving 603 citations.
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Journal ArticleDOI
Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria
TL;DR: In this article, a number of small molecule, peptide-base, liposome, and nanoparticle-based transport vectors have been proposed to facilitate transport of a variety of compounds for mitochondrial delivery.
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Molecular vehicles for mitochondrial chemical biology and drug delivery.
TL;DR: The features of existing delivery vectors developed for targeting probes and therapeutics to this highly impermeable organelle are summarized and the major applications of mitochondrial targeting of bioactive molecules are discussed, which include the detection and treatment of oxidative damage, combating bacterial infections, and the development of new therapeutic approaches for cancer.
Journal ArticleDOI
Multifunctional quantum dot DNA hydrogels.
Libing Zhang,Sae Rin Jean,Sharif Uddin Ahmed,Peter M. Aldridge,Xiyan Li,Fengjia Fan,Edward H. Sargent,Shana O. Kelley +7 more
TL;DR: Self-assembled quantum dot DNA hydrogels that exhibit both size and spectral tunability and can be used for delivery of doxorubicin, an anticancer drug, to increase potency 9-fold against cancer cells are reported.
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Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma
Ilaria Buondonno,Elena Gazzano,Sae Rin Jean,Valentina Audrito,Joanna Kopecka,Marilù Fanelli,Iris Chiara Salaroglio,Costanzo Costamagna,Ilaria Roato,Eleonora Mungo,Claudia Maria Hattinger,Silvia Deaglio,Shana O. Kelley,Massimo Serra,Chiara Riganti +14 more
TL;DR: A chemically modified mitochondria-targeted Dox (mtDox) is proposed as a new effective agent with a safer toxicity profile compared with Dox that may be effective for the treatment of Dox-resistant/Pgp-positive osteosarcoma patients, who strongly need alternative and innovative treatment strategies.
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Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell
TL;DR: Recent significant advances in mitochondrial chemical biology are highlighted, focusing on the development of chemical tools to perturb mitochondrial biochemistry, probes allowing precise measurement of mitochondrial function, and new techniques for high-throughput characterization of the mitochondrial proteome.