Saikat Dewanjee

TL;DR: Much research is required to find out new therapeutic agent/strategies for an adequate pharmacotherapy of diabetes nephropathy, where the involvement of multiple mechanisms makes it difficult to choose an optimum therapeutic agent.

TL;DR: The main aim of this review is to highlight the putative role of various mechanisms and pathways involved in the development of diabetic neuropathy and to impart an in‐depth insight on new therapeutic approaches aimed at delaying or reversing various modalities of diabetic Neuropathy.

TL;DR: The diabetic rats exhibited lower activities of superoxide dismutase, catalase, and reduced glutathione content in hepatic and renal tissues as compared with normal rats, and the activities of SOD, CAT, and GSH were found to be increased in extract treated diabetic rats in selected tissues.

TL;DR: This review critically describes the methodologies to identify antimicrobial, antioxidant, enzyme inhibitor lead/scaffolds by employing bioautography.

TL;DR: The present review aims to recapitulate the research findings on bioactive constituents of natural origin with P-gp inhibition characteristics with great potential for semi-synthetic modification to produce new scaffolds which could serve as valuable investigative tools to recognize the function of complex ABC transporters apart from evading the systemic toxicities shown by synthetic counterparts.