S
Saleh Alshamrani
Researcher at University of Leicester
Publications - 22
Citations - 116
Saleh Alshamrani is an academic researcher from University of Leicester. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 45 citations. Previous affiliations of Saleh Alshamrani include Najran University.
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Journal ArticleDOI
Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection
Youssif M. Ali,Azam Hayat,Azam Hayat,Bayad Mawlood Saeed,Kashif Syed Haleem,Kashif Syed Haleem,Saleh Alshamrani,Saleh Alshamrani,Hany I. Kenawy,Hany I. Kenawy,Viviana P. Ferreira,Gurpanna Saggu,Anna Buchberger,Anna Buchberger,Peter J. Lachmann,Robert B. Sim,Dimitrios Goundis,Peter W. Andrew,Nicholas J. Lynch,Wilhelm J. Schwaeble +19 more
TL;DR: The successful therapeutic application of a complement component, a recombinant form of properdin (Pn), with significantly higher activity than native properdin, which promotes complement activation via the alternative pathway, affording protection against N. menigitidis and S. pneumoniae is reported.
Journal ArticleDOI
Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population
Ali A. Rabaan,Muhammed A Bakhrebah,Abbas Al Mutair,Saad Alhumaid,Jumana Mansour AlJishi,Jehad Alsihati,Hawra Albayat,A. Alsheheri,Mohammed Aljeldah,Mohammed A. Garout,Wadha Alfouzan,Yousef N. Alhashem,Salma AlBahrani,Saleh Alshamrani,Sultan Alotaibi,Abdullah Alramadhan,Hanadi N. Albasha,Khalid Hajissa,Mohamad-Hani Temsah +18 more
TL;DR: Comparing health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022 is established.
Journal ArticleDOI
Updated Insights into the T Cell-Mediated Immune Response against SARS-CoV-2: A Step towards Efficient and Reliable Vaccines
Manish Dhawan,Ali A. Rabaan,Mahmoud M. Fawarah,Souad A. Almuthree,Roua A. Alsubki,Amal Alfaraj,Mutaib M Mashraqi,Saleh Alshamrani,W Abduljabbar,Ameen S. S. Alwashmi,Fatimah Al Ibrahim,Abdulmonem A. Alsaleh,Faryal Khamis,Jameela Alsalman,M. Sharma,Talha Bin Emran +15 more
TL;DR: In this paper , an updated review has been developed to understand the involvement of T cells in the infection mechanism, which in turn determines the prognosis of the disease, and also focused on the T cells' exhaustion under certain conditions and how these functional perturbations can be modulated for an effective immune response against SARS-CoV-2.
Journal ArticleDOI
Suspected Adenovirus Causing an Emerging HEPATITIS among Children below 10 Years: A Review
Ali A. Rabaan,Muhammed A Bakhrebah,Majed S. Nassar,Zuhair S. Natto,Abbas Al Mutair,Saad Alhumaid,Mohammed Aljeldah,Mohammed A. Garout,Wadha Alfouzan,F. Alshahrani,Tarek Sulaiman,Meshal K. AlFonaisan,Mubarak Alfaresi,Saleh Alshamrani,Firzan Nainu,Shin Jie Yong,Om P. Choudhary,Naveed Ahmed +17 more
TL;DR: The suspected cause of acute hepatic failure in the United States of America is adenovirus, including its genomic variations, because its pathogenesis and laboratory investigations have been positively linked.
Journal ArticleDOI
Hemi-Babim and Fenoterol as Potential Inhibitors of MPro and Papain-like Protease against SARS-CoV-2: An In-Silico Study
Ahmad A. Alzamami,Norah A. Alturki,Y. Alghamdi,Shaban Ahmad,Saleh Alshamrani,S. Asiri,Mutaib M Mashraqi +6 more
TL;DR: Hemi-Babim and Fenoterol are a beta-2 adrenergic agonist used for the symptomatic treatment of asthma as a bronchodilator and tocolytic and performed well in molecular dynamics simulation studies, providing evidence that the said drugs can work against the MPro and papain-like protease, which are the main drug targets.